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Effects of The Combination of Seluang Fish (Rasbora spp.) and Pasak Bumi (Eurycoma Longifolia Jack) on Systemic Inflammation and Neurotransmitter in Stunting Model Rat (Rattus Novergicus)
(1) Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
(2) Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
(3) Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
(4) Brawijaya University, Malang, East Java, Indonesia
(5) Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia
(*) Corresponding Author
Abstract
Background: Stunting causes growth and development issues which are characterized by a systemic inflammatory response and neurotransmitter disorder. The South Kalimantan natural resources i.e. extracts of Pasak Bumi (Eurycoma longifolia Jack) and seluang fish have the potential as a modified therapy for stunting management.
Objective: To analyze the effect of Pasak Bumi and seluang fish administration in overcoming systemic inflammation and neurotransmitter disorders in the stunting rats model.
Methods: Rats were divided into six group i.e Positive Control (KP): Stunting rats + placebo + standard feed; (P1): stunting rats + 70% EPB 15 mg/kg body weight (BW) + standard feed; (P2): Stunting rats + DHA 1 mg/kg BW + standard feed; (P3): Stunting rats + EPB 15 mg/kg BW + DHA 1 mg/kg BW + standard feed; (P4): Stunting rats + seluang fish; (P5): Stunting rats + EPB 15 mg/kg BW + seluang fish for 5 weeks; Parameters measured were levels of IL-6, TNF-α, and serotonin.
Results: There were significant differences in levels of TNF-α (p = 0.000) and serotonin (p = 0.000).
Conclusion: The administration of Pasak Bumi extract and seluang fish was able to inhibit systemic inflammation and neurotransmitter dysregulation.Keywords
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DOI: https://doi.org/10.26714/magnamed.10.1.2023.27-39
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