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The Effect of Neutrophil Lymphocyte Ratio and Bacterial Co-Infection on Mortality and Length of Hospital Stay of COVID-19 Patients
(1) Faculty of Medicine, Sebelas Maret University, Surakarta, Central Java, Indonesia
(2) Department of Pulmonology, Faculty of Medicine, Sebelas Maret University, Surakarta, Central Java, Indonesia
(3) Department of Histology, Faculty of Medicine, Sebelas Maret University, Surakarta, Central Java, Indonesia
(*) Corresponding Author
Abstract
Background: The new coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious disease. The disease has spread rapidly and widely around the world, and was declared as pandemic in March 2020 by WHO. The neutrophil lymphocyte ratio (NLR) is a biomarker that provides important information about the status of systemic inflammation, including in COVID-19. Bacterial co-infection is commonly identified in viral respiratory tract infections such as SARS-CoV-2 and is an important cause of morbidity and mortality.
Objective: This study aims to retrospectively analyze clinical data of COVID-19 patients who were treated at Dr. Moewardi General Hospital in Surakarta, to determine the effect of NLR and bacterial co-infection with mortality and length of hospital stay of COVID-19 patients.
Methods: This study is an analytical observational study with a cross-sectional design using secondary data from 87 adult COVID-19 patients at Dr. Moewardi Hospital in August 2021. The sampling method used was purposive sampling of all adult patients aged 18 years or above who had been diagnosed with COVID-19 and hospitalized.
Results: It was found that there was a strong effect of bacterial co-infection on NLR (r= 0.528). It was also found that NLR and bacterial co-infection simultaneously affected the length of hospital stay (Sig.= 0.02) and mortality (Sig.= 0.027). Partially, the effect of NLR on length of hospital stay was found (Sig.= 0.045).
Conclusion: NLR and bacterial co-infection have an effect on mortality and length of hospital stay of COVID-19 patients.Keywords
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DOI: https://doi.org/10.26714/magnamed.11.2.2024.122-129
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