![一般社団法人全国医学部国際交流協議会[J-MICA (Japanese Medical University International Collaborative Assembly)]](http://kokusaikouryu.net/img/banner01.png)
The Potential of Noni (Morinda citrifolia L.) as an Anti-Diabetic
(1) Department of Biochemistry, Faculty of Medicine, University of Jenderal Soedirman, Purwokerto, Indonesia
(2) Department of Internal Medicine, Faculty of Medicine, University of Jenderal Soedirman, Purwokerto, Indonesia
(3) Department of Obstetrics and Gynecology, Faculty of Medicine, University of Jenderal Soedirman, Purwokerto, Indonesia
(4) Department of Anatomy, Faculty of Medicine, University of Jenderal Soedirman, Purwokerto, Indonesia
(*) Corresponding Author
Abstract
Background: Diabetes Mellitus (DM) is still a major health problem in the world today because the prevalence remains increasing. Type 2 diabetes is the most common type of diabetes, accounting for over 90% of all diabetes cases. This disease is characterized by insulin resistance, where the body cannot fully respond to insulin. As a result, glucose levels in the blood continue to increase (hyperglycemia). The main of Type 2 DM management is a healthy lifestyle. In addition, pharmacological therapy is also needed to keep blood glucose levels in diabetics under control. However, antidiabetic medicines can cause some side effects. Therefore, the development of alternative diabetes therapy has been done to minimize side effects. One of the herbal ingredients that are being studied for its potential as an anti-diabetic is noni (Morinda citrifolia L.).
Objective: The aim of the study is to review and find out more about the potential of noni (Morinda citrifolia L.) as an anti-diabetic.
Methods: This research is included in the type of literature review. The kinds of literature are English and Indonesian language research articles related to the topic searched by using database sources from ProQuest, PubMed, ScienceDirect, and Google Scholar. The research articles were published in the last 10 years (2012 to 2022).
Results: There are 14 kinds of literature that match the topic of study. A total of 12 kinds of literature are in vivo studies on animals and 2 literature studies on humans. The result shows that noni has an antidiabetic effect by lowering blood glucose levels and improving other parameters. Parts of Noni that have the potential to control Type 2 DM are fruit and leaves, which can be in the form of extracts, juices, or fermented products. Further research is needed to evaluate the toxicity, the content of active compounds, and the expression of genes related to Type 2 DM for ensuring the mechanism of noni in controlling hyperglycemia. Human studies with more respondents are also needed to confirm the findings of existing studies.
Conclusion: Noni has an antidiabetic effect by lowering blood glucose levels and improving other parameters. Based on human studies, noni fruit juice can serve as a suitable addition to the diet of Type 2 DM patients.
Keywords
Full Text:
PDFReferences
Webber, S. 2013. IDF Diabetes Atlas 10th Edition. International Diabetes Federation, Diabetes Research and Clinical Practice 102(2): 147-148. doi:10.1016/j.diabres.2013.10.013.
IDF. 2020. "About Diabetes". Available from: URL https://www.idf.org/aboutdiabetes/type-2-diabetes.html/ Diakses 12 Desember 2022.
Chaudhury, A., Chitharanjan, D., Vijaya, S.R.D., et al. 2017. Clinical Review of Antidiabetic Drugs: implications for Type 2 Diabetes Mellitus Management. Frontiers in Endocrinology, 8.
Mcclatchey WC. Diversity of Growth Forms and Uses in the Morinda citrifolia L. Complex. Univ Hawaii CTAHR - Coop Ext Serv. 2003;(January):5–10.
Wang, M.Y. Brett, J.W., Jarakae, J., Diane, N., SU, C., Afa, K.P., Gary, A. 2002. Morinda citrifolia (Noni): A literature review and recent advances in Noni research', Acta Pharmacologica Sinica 23(12): 1127–1141.
Wulandari, A. dan Lakiu, D.R. 2022. Uji Efek Ekstrak Daun Mengkudu Terhadap Penurunan Glukosa Darah Tikus Putih yang Diinduksi Streptozotocin. Farmakologika Jurnal Farmasi 19(1):1–13.
7 Radiansah, R., Rahman, N., dan Nuryanti, S. 2013. Ekstrak Daun Kelor (Moringa oleivera) Sebagai Alternatif Untuk Menurunkan Kadar Gula Darah Pada Mencit. Jurnal Akademika Kim 2(2): 54-61.
Andrie, M., Taurina, W., dan Ayunda, R. 2014. Activities Test Of "Jamu Gendong Kunyit Asam (Curcuma domestica L) As An Antidiabetic in Streptozotocin-Induced Rats. Traditional Medicine Jounal 19 (2): 101.
Zega, V.L., Pemsi, M.W., Christi, M. 2016. Uji beberapa dosis ekstrak buah mengkudu (Morinda citrifolia l.) terhadap kadar glukosa darah pada tikus wistar (Rattus norvegicus) yang diinduksi aloksan. Jurnal e-Biomedik 4(2).
Johnson, M.D., Gad, S.C. 2007. The Rat. Dalam: Gad SC. Animal Models in Toxicology Edisi ke-2. New York. Taylor & Francis.
Mukhriani, M., Rauf, A. dan Purnamasari, I. 2018. Efek Antihiperglikemik Fraksi-Fraksi Daging Buah Mengkudu (Morinda citrifolia L.) pada Tikus Putih Jantan. ad-Dawaa' Journal of Pharmaceutical Sciences 1(2). doi:10.24252/djps.v1i2.11409.
Musfiroh, I., Syifa, K.A., dan Muhtadi, A. 2020. Uji Antidiabetes Fraksi Air, Etil Asetat Dan n-heksan Buah Mengkudu (Morinda citrifolia L.) Pada Tikus Putih Metode Induksi Aloksan. Jurnal Farmasi Galenika 7(2): 60–70.
Haque, M. and Rao, U.S.M. 2013. Modulatory effect of Mengkudu fruit on the activities of key enzymes of glucose synthesis and utilization pathways of diabetic induced rats. Journal of Pharmacy Research 7(1): 53–61. doi:10.1016/j.jopr.2013.01.003
Lidia, L. 2016. Pengaruh Infusa Buah Mengkudu (Morinda Citrifolia, L.) terhadap Kadar Glukosa Darah Tikus Putih Jantan Galur Wistar yang Dibebani Glukosa. Jurnal Ilmiah Bakti Farmasi 1(2): 33–42
Sari, S.P., Munim, A. dan Fitriani, S.W. 2012. Pengaruh Pemberian Sari Buah Mengkudu (Morinda citrifolia Linn.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes. Pharmaceutical Sciences and Research 9(1). doi:10.7454/psr.v9i1.3363.
Achmad, N. dan Jenie, I.M. 2012. Efek Hipoglikemik Jus Buah Morinda citrifolia pada Tikus Diabetik. Mutiara Medika 12(2): 88-92.
Nayak, B.S., Marshal, J.R., Isitor, G., dan Adogwa. 2011. Hyploglicemic and Hepatoprotective Activity of Fermented Fruit Juice of Morinda citrifolia (Noni) in Diabetic Rats. Evid Based Complement Alternat Med, 1-5.
Santoso, B.S.A., Sudarsono, Agung, E.N., Yosi, B.M. 2018. Hypoglycemic activity and pancreas protection of combination of Morinda citrifolia Linn. juice and Curcuma xanthorrhiza Roxb. juice on streptozotocin-induced diabetic rats. Indonesian Journal of Pharmacy 29(1): 16–22. doi:10.14499/indonesianjpharm29iss1pp16.
Santoso, B.S.A., Nugroho, A.E. dan Murti, Y.B. 2015. Effect of Mixture of Mengkudu and Temulawak Juices on MDA Levels and SOD Activity in Streptozotocin-induced Diabetic Rats Liver. 1–4.
Chang, W.C., Wu, S.C., Xu, K.D., Liao, B.C., Wu, J.F., Cheng, A.S. 2015. Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. Molecules 20: 2786–2801.
Borra, S.K., Gurumurthy, P., Mahendra, J., others. 2013. Antioxidant and free radical scavenging activity of curcumin determined by using different in vitro and ex vivo models. J. Med. Plants Res. 7: 2680–2690.
Kim, A.J., Kim, Y.O., Shim, J.S., Hwang, J.K. 2007. Immunostimulating activity of crude polysaccharide extract isolated from Curcuma xanthorrhiza Roxb. Biosci. Biotechnol. Biochem. 71: 1428–1438.
Yadav, V.S., Mishra, K.P., Singh, D.P., Mehrotra, S., et al. 2005. Immunomodulatory effects of curcumin. Immunopharmacol. Immunotoxicol. 27: 485–497.
Wu, W., Geng, H., Liu, Z., Li, H., Zhu, Z. 2014. Effect of curcumin on rats/mice with diabetic nephropathy: a systematic review and Meta-analysis of randomized controlled trials. J. Tradit. Chin. Med. 34: 419–429.
Wresdiyati, T., Astawan, M., dan Hastanti, L. Y. 2006. Profil Imunohistokimia Superoksida Dismutase (SOD) pada Jaringan Hati Tikus dengan Kondisi Hiperkolesterolemia. HAYATI Journal of Biosciences 13(3): 85–89.
Laelatunisa, N. Nikmatul, R., Rachmadanti, A., Rista, A. 2019. Efek Penambahan Sari Buah Mengkudu (Morinda citrifolia L.) pada Roti Tawar terhadap Kadar Glukosa Darah Pada Tikus yang Diinduksi Aloksan. Food Technology and Halal Science Journal 2(2): 282. doi:10.22219/fths.v2i2.12992.
Potterat, O. dan Hamburger, M. 2007. Morinda citrifolia (noni) fruit phytochemistry, pharmacology, safety. Planta Med. J 73: 191-199.
Lee, S.Y., So, L.P., Jin, T.H., Sung, H.Y., Young, D.N., Seong, IL 2012. Antidiabetic effect of morinda citrifolia (Noni) fermented by cheonggukjang in KK-A y diabetic mice. Evidence-based Complementary and Alternative Medicine. doi:10.1155/2012/163280.
Algenstaedt, P., Stumpenhagen, A. dan Westendorf, J. 2018. The Effect of Morinda citrifolia L. Fruit Juice on the Blood Sugar Level and Other Serum Parameters in Patients with Diabetes Type 2. Evidence-based Complementary and Alternative Medicine. doi:10.1155/2018/3565427
Dafriani, P., Mutiara, K., Siska, S.A., Roza, M. 2020. The Potential of Noni (Moringa citrifolia) in Lowering Blood Glucose Levels in Diabetes Mellitus Patients. Bioeduscience 4(2): 120-123.
Article Metrics
Abstract view : 76 timesPDF - 28 times
DOI: https://doi.org/10.26714/magnamed.11.1.2024.83-96
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Indexed by
MAGNA MEDIKA by APKKM is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.