![一般社団法人全国医学部国際交流協議会[J-MICA (Japanese Medical University International Collaborative Assembly)]](http://kokusaikouryu.net/img/banner01.png)
The Effect of Dobutamine Administration on Oxygen Saturation in Infant's Persistent Pulmonary Hypertension of The Newborn (PPHN)
(1) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia
(2) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia
(3) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia
(4) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia
(5) Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia
(*) Corresponding Author
Abstract
Background: PPHN of infants are severe cases because the rate of disability and death in infants is relatively high, reaching around 10-20% of cases. Therefore, prompt, accurate, and rational management is needed to reduce cases number of records and deaths. The incidence of PPHN is 2-6 out of 1000 live births; in Surabaya, the incidence was 42 babies per 1000 live births from April to September 2017. Dobutamine is an effective therapy that can support good morbidity and mortality. Therefore, therapeutic options in infants with PPHN in the form of dobutamine are often used.
Objective: To determine the effect of dobutamine administration on oxygen saturation in infants with persistent pulmonary hypertension of the newborn (PPHN)
Method: A cross-sectional design with a consecutive sampling of 50 infants with PPHN who received dobutamine therapy at the Hospital of Siti Khodijah Muhammadiyah Sepanjang. Data collection using medical records.
Results: The average increase in oxygen saturation before and after being given dobutamine was 36.0%. No difference in the increase in oxygen saturation based on the duration of dobutamine administration. The dobutamine dose's effect on the oxygen saturation increase in infants with PPHN.
Conclusion: The results of this study indicate a significant effect of dobutamine administration on increasing oxygen saturation in PPHN infants.
Keywords
Full Text:
PDFReferences
Ontoseno T, Morton SU, Brodsky D. Penyakit Jantung Pada Anak. Edisi 1. Clinics in Perinatology. Surabaya: Sagung Seto; 2018.
Anas M, Marlina U. Penggunaan Nitrovasodilator Sebagai Donor Oksida Nitrik Pada Preeklamsia. In: Proceeding Annual Meeting APKKM Ke 6 Surabaya [Internet]. ID; 2018. p. 1–27. Available from: http://journal.um-surabaya.ac.id/index.php/Pro/search/search?simpleQuery=anas&searchField=query
Bendapudi P, Rao GG, Greenough A. Diagnosis and management of persistent pulmonary hypertension of the newborn. Paediatr Respir Rev. 2015;16(3):157–61.
de Brito VLG, Pinheiro M, Sazima M. Sophora tomentosa and Crotalaria vitellina (Fabaceae): Reproductive biology and interactions with bees in the restinga of ubatuba, sǎo paulo. Biota Neotrop [Internet]. 2010;10(1):185–92. Available from: http://www.biotaneotropica.org.br/v10n1/en/abstract?article+bn03310012010
Anas M, Triastuti N, Airlangga MP. Role Of Inhaled Nitric Oxides In Pregnancy With Eisenmenger Syndrome. QANUN Med [Internet]. 2020;1(4):11–26. Available from: http://journal.um-surabaya.ac.id/index.php/qanunmedika/article/view/3478
LASMONO SF. Efikasi Dan Safety Beraprost Dalam Menurunkan Tekanan Arteri Pulmonalis Pada Hipertensi Arteri Pulmonalis Terkait Penyakit Jantung Bawaan Pirau Kiri Ke Kanan. Surabaya: Universitas Airlangga; 2018.
Faadhilah A, Airlangga MP, Yuliyanasari N, Djalilah GN. Association between gestational age and persistent pulmonary hypertension of the newborn (PPHN) severity in preterm babies at Sidoarjo Regional Hospital. Qanun Med - Med J Fac Med Muhammadiyah Surabaya. 2021;5(1):77.
Istiantoro Y., Setiabudy R. Tuberkulosis Farmakologi dan Terapi. Edisi 5. Indonesia DF dan TFK, editor. Fkui. Jakarta: Balai Penerbit FKUI; 2007. 613–615, 774–775 p.
Torfs CP, Christianson RE. Anomalies in Down syndrome individuals in a large population-based registry. Am J Med Genet. 1998;77(5):431–8.
Prima Maulana Cahyo Nugroho, Lilia Dewiyanti AR. Tingkat keparahan asfiksia neonatorum pada bayi berat lahir rendah (bblr). Kedokt Muhammadiyah. 2015;2(1):43–6.
Merlos P, Núñez J, Sanchis J, Miñana G, Palau P, Bodí V, et al. Echocardiographic estimation of pulmonary arterial systolic pressure in acute heart failure. Prognostic implications. Eur J Intern Med. 2013;24(6):562–7.
Katzung BG 2015. Handbook Farmakologi Dasar dan Klinik. Edisi 12. Jakarta: EGC; 2015.
Puthiyachirakkal M, Mhanna MJ. Pathophysiology, management, and outcome of persistent pulmonary hypertension of the newborn: A clinical review. Front Pediatr. 2013;1(SEP):23.
Triastuti N, Airlangga MP, Anas M. Usage of Inhaled Nitric Oxides in Cases of Eisenmenger Syndrome. Indones J Med Sci Public Heal. 2020;1(1):13–9.
Kakkar RK. Continuous Positive Airway Pressure. Encyclopedia of Sleep. Bandung; 2013. 490–499 p.
S W, A T. Pediatric Intensive Care - Google Buku [Internet]. JA K, editor. Pittsburgh, Pennsylvania: Oxford University Press; 2017. Available from: https://books.google.co.id/books?hl=id&lr=&id=4QFLDgAAQBAJ&oi=fnd&pg=PA99&dq=info:8ZZWiSWBgicJ:scholar.google.com/&ots=DDnBmDhPjJ&sig=iFtWjMuOLBL0al0x0dpHVbd
Bakker J, Coffernils M, Leon M, Gris P, Vincent JL. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest [Internet]. 1991;99(4):956–62. Available from: http://journal.chestnet.org/article/S001236921648760X/fulltext
Dickinson JD, Kollef MH. Early and adequate antibiotic therapy in the treatment of severe sepsis and septic shock. Curr Infect Dis Rep [Internet]. 2011;13(5):399–405. Available from: www.nejm.org
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368–77.
Article Metrics
Abstract view : 445 timesPDF - 88 times
DOI: https://doi.org/10.26714/magnamed.9.2.2022.147-154
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Indexed by
MAGNA MEDIKA by APKKM is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.