The Impact of Blood Glucose Levels on Acid-Fast Bacteria Conversion in Tuberculosis Patients with Diabetes Mellitus

Shahrul Rahman(1*), Andhyka Libawardana Pulungan(2), Kebba S. Bojang(3)


(1) [Scopus ID: 57220181149] FK UMSU, Medan
(2) Universitas Muhammadiyah Sumatera Utara
(3) School of Medicine And Alllied Health Sciences, University of The Gambia, The Gambia
(*) Corresponding Author

Abstract


Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Pulmonary tuberculosis in DM sufferers will aggravate hyperglycemia and spur ketoacidosis.

Objective: To determine the effect of blood glucose levels on the conversion of acid-fast bacteria (AFB) in TB patients with DM

Methods: This research is descriptive-analytical with a retrospective cohort approach. The data are taken as data from TB patients with DM at the Pulmonary Hospital of North Sumatera Province from July 2018-September 2019. The sample is pulmonary tuberculosis-positive AFB patients with high blood glucose levels, which was carried out with total sampling. The sample used in the study was 49 patients who met the inclusion criteria.

Results: There was that in the category of increased blood glucose levels with AFB converted by 4 (7.3%) respondents, while those who were not converted were 6 (2.7%) respondents. The category of decreased blood glucose levels with AFB was converted by 32 (28.7%) respondents, while 7 (10.3%) respondents were not converted. The p-value shows 0.014, which means the effect of blood glucose on the conversion of acid-fast bacteria has a significant relationship.

Conclusion:There is a significant relationship between the effect of blood glucose levels on acid-fast bacteria conversion.


Keywords


Blood Glucose Levels; Tuberculosis; AFB; Diabetes Mellitus

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References


Smith I. Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence. Clinical Microbiology Reviews. 2013. 16 (3). 463-496

Casqueiro J, Casqueiro J, and Alves C. Infections in patients with diabetes mellitus: A review of pathogenesis. Indian Journal of Endocrinology and Metabolism. 2012. 16 (Suppl 1), S27-S36.

American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2009. 32 (S1), 562-567.

Mihardja L, Soetrisno U, and Soegondo S. Prevalence and clinical profile of diabetes mellitus in productive aged urban Indonesians. J Diabetes Invest. 2014. 5 (5), 507-512

Dooley KE, and Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis. 2009, 9(12): 737–746.

Restrepo BI. Diabetes and tuberculosis. Microbiol Spectr. 2016; 4(6): 1-19.

Siddiqui AN, Khayyam KU, and Sharma M. Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study. BioMed Research International. 2016, 1-11

Dooley KE, Tang T, Golub JE, Dorman SE, and Cronin W. Impact of Diabetes Mellitus on Treatment Outcomes of Patients with Active Tuberculosis. Am J Trop Med Hyg. 2009; 80(4): 634–639.

Baghaei P, Marjani M, Javanmard P, Tabarsi P, and Masjedi MR. Diabetes mellitus and tuberculosis facts and controversies. Journal of Diabetes & Metabolic Disorders 2013, 12(58), 1-8

Lengkong JVM. Characteristics Of Patients With Pulmonary Tuberculosis, Side Effects Of Antituberculosis Drugs, And Accuracy Of Diagnosis Of Patients With Pulmonary Tuberculosis. European Journal of Molecular & Clinical Medicine 2020, 07 (03), 4752-4770

Narasimhan P, Wood J, MacIntyre CR, and Mathai D. Risk Factors for Tuberculosis. Pulmonary Medicine 2013, 1-11

RaghuramanS, VasudevanKP, Govindarajan S, Chinnakali P, Panigrahi KC. Prevalence of Diabetes Mellitus among Tuberculosis Patients in Urban Puducherry. North American Journal of Medical Sciences 2014, 6(1), 30-34.

Tenaye L, Mengiste B, Baraki N, Mulu E. Diabetes Mellitus among Adult Tuberculosis Patients Attending Tuberculosis Clinics in Eastern Ethiopia. BioMed Research International 2019, 1-7

Sajith, M., et al. 2015. Socio-Demographic characteristics of tuberculosis patients in a tertiary care hospital. International Journal of Medical and Health Research, 1(3): 25-28

Putra ON, Damayanti A, Nurrahman NWD, Devi T, Aluf W. Evaluation of Category I of Anti-tuberculosis Therapy in Intensive Phase Pulmonary TB by Conversion of Acid-Fast Bacilli Sputum. Pharmaceutical Sciences and Research 2019, 6(3), 183 - 188

Trebucq A, Schwoebel V, Kashongwe Z, et al. Treatment outcome with a short multidrug-resistanttuberculosis regimen in nine African countries. Int J Tuberc Lung Dis 2018, 22(1):17–25

Fachri M, Hatta M, Abadia S, et al. Comparison of acid-fast bacilli (AFB) smear for Mycobacterium tuberculosis on adult pulmonary tuberculosis (TB) patients with type 2 diabetes mellitus (DM) and without type 2 DM. Respiratory Medicine Case Reports 2018, 23: 158–162

Yorke E, Atiase Y, Akpalu J, Kantanka OS, Boima V, Dey ID. The Bidirectional Relationship between Tuberculosis and Diabetes. Tuberculosis Research and Treatment 2017, 1-6

Kelwade J, Parekh H, and Sethi BP. How many oral anti diabetic drugs before insulin? Indian Journal of Endocrinology and Metabolism 2017, 21 (1): 249-250

Geerlings SE, Hoepelman AIM. Immune dysfunction in patients with diabetes mellitus (DM).Immunology and Medical Microbiology 1999, 26 259-265

Yoon YS, Jung JW, Jeon EJ, Seo H, Ryu YJ, Yim JJ, et al. The effect of diabetes control status on treatment response in pulmonary tuberculosis: A prospective study. Thorax. 2017;72(3):263–70.


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DOI: https://doi.org/10.26714/magnamed.9.2.2022.120-127

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