Co-Existence of Tuberculosis and Lung Cancer
(1) RSUP Dr. M. Djamil Padang, West Sumatera, Indonesia
(2) Department of Pulmonology and Respiratory Medicine, Faculty of Andalas University/RSUP Dr. M. Djamil, Padang, West Sumatera, Indonesia
(3) Department of Pulmonology and Respiratory Medicine, Faculty of Andalas University/RSUP Dr. M. Djamil, Padang, West Sumatera, Indonesia
(4) Department of Pulmonology and Respiratory Medicine, Faculty of Andalas University/RSUP Dr. M. Djamil, Padang, West Sumatera, Indonesia
(*) Corresponding Author
Abstract
Background: Tuberculosis (TB) and lung cancer cause significant morbidity and mortality worldwide and pose a global health threat. Each year these two diseases account for more than 1.6 million deaths worldwide. The incidence of both diseases is still high in many developing countries, especially in Asian countries. TB and lung cancer are often confused and misdiagnosed, especially in countries with diagnostic challenges of low TB incidence and risk of missed diagnosis.
Case Presentation: The following is a case report of a 53-year-old male patient diagnosed with pulmonary TB accompanied by right lung cancer, and the same respiratory complaints can be had by lung cancer and TB. However, the presence of facial edema (part of the superior vena cava syndrome) causes clinicians to focus more on lung cancer so that the diagnosis of TB is often overlooked.
Conclusion: Tuberculosis should be a significant concern, especially in patients with malignancies such as lung cancer and located in TB endemic areas. Delay in diagnosis and or miss diagnosis will affect the patient's outcome.Keywords
Full Text:
PDFReferences
Shiels MS, Albanes D, Virtamo J, Engels EA. Increased risk of lung cancer in men with tuberculosis in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev. 2011;20(4):672–8.
Tamura A. Tuberculosis and Lung Cancer. Kekkaku. 2019;18–21.
Bae JM, Li ZM, Shin MH, Kim DH, Lee MS, Ahn YO. Pulmonary tuberculosis and lung cancer risk in current smokers: The Seoul male cancer cohort study. J Korean Med Sci. 2013;28(6):896–900.
Bhatt MLB, Kant S, Bhaskar R. Pulmonary tuberculosis as differential diagnosis of lung cancer. South Asian J Cancer. 2012;1(1):36–42.
Burhan E, Isbaniah F, Sinaga bintang Y, Yanifitri DB, Handayani D, Isa M, et al. Tuberkulosis – Pedoman diagnosis dan penatalaksanaan di Indonesia. Perhimpunan dokter paru Indonesia (PDPI). 2021. 12–26 p.
Liang HY, Li XL, Yu XS, Guan P, Yin ZH, He QC, et al. Facts and fiction of the relationship between preexisting tuberculosis and lung cancer risk: A systematic review. Int J Cancer. 2009;125(12):2936–44.
Ghebreyesus TA. Global Tuberculosis Report. 2020. 5–18 p.
Kementrian Kesehatan Indonesia. Pedoman Nasional Pelayanan Kedokteran Kanker paru. 2017;8–16.
Ho JC man, Leung CC. Management of co-existent tuberculosis and lung cancer. Lung Cancer. 2018;122:83–7.
Cicenas S, Vencevičius V. Lung cancer in patients with tuberculosis. World J Surg Oncol. 2007;5:1–5.
Rihawi A, Huang G, Al-Hajj A, Bootwala Z. A case of tuberculosis and adenocarcinoma coexisting in the same lung lobe. Int J Mycobacteriology. 2016;5(1):80–2.
Chen C-Y, Wang J-Y, Chien Y-C, Chen K-Y, Yu C-J, Yang P-C. Lung cancer mimicking pulmonary tuberculosis in a TB-endemic country: the role of early invasive diagnostic procedures. Lung Cancer Manag. 2015;4(1):9–16.
Cukic V. The Association Between Lung Carcinoma and Tuberculosis. Med Arch (Sarajevo, Bosnia Herzegovina). 2017;71(3):212–4.
Nugroho NP, Wati FF. Koeksistensi Kanker Paru Dan Tuberkulosis. Syifa’ Med J Kedokt dan Kesehat. 2020;11(1):49.
Çakar B, Çiledağ A. Evaluation of coexistence of cancer and active tuberculosis; 16 case series. Respir Med Case Reports. 2018;23(7):33–7.
Falagas ME, Kouranos VD, Athanassa Z, Kopterides P. Tuberculosis and malignancy. Qjm. 2010;103(7):461–87.
Harikrishna J, Sukaveni V, Kumar D, Mohan A. Cancer and tuberculosis. Indian Acad Clin Med. 2012;37–9.
Sunaga N, Kaira K. Epiregulin as a therapeutic target in non-small-cell lung cancer. Lung Cancer Targets Ther. 2015;6:91–8.
Jacobs REA, Gu P, Chachoua A. Reactivation of pulmonary tuberculosis during cancer treatment. Int J Mycobacteriology. 2015;4(4):337–40.
Fol M, Koziński P, Kulesza J, Białecki P, Druszczyńska M. Dual nature of relationship between mycobacteria and cancer. Int J Mol Sci. 2021;22(15).
Hammen I. Tuberculosis mimicking lung cancer. Respir Med Case Reports. 2015;16:45–7.
Chung HS, Lee JH. Bronchoscopic assessment of the evolution of endobronchial tuberculosis. Chest. 2000;117(2):385–92.
Aviani J, EH SM, Haryatie I, Raharjo F, Sutanto YS, Setijadi AR. The Delay in The Diagnosis of Lung Cancer Due to Misdiagnosis as Pulmonary Tuberculosis. J Respirologi Indones. 2017;37(4):288–92.
Sihoe ADL, Shiraishi Y, Yew WW. The current role of thoracic surgery in tuberculosis management. Respirology. 2009;14(7):954–68.
Zack MB, Davis DO, Stein E. Radiotherapy in Chest Malignant Tumors. Ther Radiol. 2017;645–8.
Hirashima T, Tamura Y, Han Y, Hashimoto S, Tanaka A, Shiroyama T, et al. Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: A retrospective study 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis. BMC Cancer. 2018;18(1):1–10.
Article Metrics
Abstract view : 837 timesPDF - 198 times
DOI: https://doi.org/10.26714/magnamed.9.1.2022.51-61
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Indexed by
MAGNA MEDIKA by APKKM is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.