Genetika terhadap Penyakit Bipolar

Raden Ajeng Aprida Putri Kumala Ayu(1*)


(1) Fakultas Kedokteran, Universitas Lampung
(*) Corresponding Author

Abstract


Gangguan mood yang paling umum adalah gangguan depresi mayor dan gangguan bipolar. Patofisiologi gangguan bipolar bersifat kompleks, multifaktorial, dan tidak sepenuhnya dipahami. Beberapa penelitian terbaru membuka wawasan dan untuk menemukan biomarker baru untuk Gangguan Bipolar. Sebaliknya, biomarker baru memfasilitasi tidak hanya diagnosis gangguan dan pemantauan efek biologis pengobatan, tetapi juga perumusan hipotesis baru tentang penyebab dan patofisiologi Gangguan Bipolar. Gangguan Bipolar ditandai oleh beberapa asosiasi antara perkembangan otak yang terganggu, neuroplastisitas, dan kronobiologi, yang disebabkan oleh: faktor genetik dan lingkungan; gangguan pada apoptosis, inflamasi imun, neurotransmitter, neurotropin, dan jalur pensinyalan kalsium; stres oksidatif dan nitrosatif; bioenergi seluler; dan transportasi membran atau vesikular. Penelitian gangguan bipolar saat ini dikaji, termasuk proses patofisiologis terkait dan biomarker kunci, yang telah dikaitkan dengan perubahan genetika. Penyakit Bipolar dinilai dapat membahayakan jiwa sehingga pengobatan yang tepat dapat berhasil jika diagnosis yang dibuat tepat dan pengobatan dimulai sejak dini. Akibatnya, upaya besar telah dilakukan. Tinjauan pustaka ini membahas peran genetika terhadap penyakit bipolar dengan cara mengidentifikasi faktor risiko genetik atau biomarker yang akan mengidentifikasi individu yang berisiko. Didapatkan hasil bahwa terdapat perubahan genetika, struktur, fungsi, fisiologi, dan neurokimia otak pada gangguan Bipolar, terutama perubahan neuroplastisitas, peradangan saraf, jalur pensinyalan intraseluler, bioenergi, stres oksidatif dan nitrosatif, apoptosis dan proteolisis, pensinyalan kalsium, dan transportasi membran atau vesikular dan diharapkan penelitian selanjutnya dapat mengembangkan potensi genetika dalam hubungannya dengan bipolar.


Keywords


bipolar; genetika; gangguan mood

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References


American Psychiatric Association. (2013). American Psychiatric Association, 2013. Diagnostic and statistical manual of mental disorders (5th ed.). In American Journal of Psychiatry. https://doi.org/10.1176/appi.books.9780890425596.744053

Cardno, A. G., & Owen, M. J. (2014). Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbu016

Carlson, G. A., & Pataki, C. (2016). Understanding Early Age of Onset: A Review of the Last 5 Years. In Current Psychiatry Reports. https://doi.org/10.1007/s11920-016-0744-8

Cooper, R. (2017). Diagnostic and statistical manual of mental disorders (DSM). In Knowledge Organization. https://doi.org/10.5771/0943-7444-2017-8-668

Craddock, N., & Sklar, P. (2013). Bipolar Disorder 1—Genetics of bipolar disorder. In The Lancet. https://doi.org/10.1016/S0140-6736(13)60855-7

Geddes, J. R., & Miklowitz, D. J. (2013). Treatment of bipolar disorder. In The Lancet. https://doi.org/10.1016/S0140-6736(13)60857-0

Grande, I., Berk, M., Birmaher, B., & Vieta, E. (2016). Bipolar disorder. In The Lancet. https://doi.org/10.1016/S0140-6736(15)00241-X

Hauser, M., Galling, B., & Correll, C. U. (2013). Suicidal ideation and suicide attempts in children and adolescents with bipolar disorder: A systematic review of prevalence and incidence rates, correlates, and targeted interventions. In Bipolar disorders. https://doi.org/10.1111/bdi.12094

Heinrich, A., Lourdusamy, A., Tzschoppe, J., Vollstädt-Klein, S., Bühler, M., Steiner, S., Bach, C., Poustka, L., Banaschewski, T., Barker, G., Büchel, C., Conrod, P., Garavan, H., Gallinat, J., Heinz, A., Ittermann, B., Loth, E., Mann, K., Martinot, J. L., … Nees, F. (2013). The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing. Bipolar Disorders. https://doi.org/10.1111/bdi.12068

Kenny, E. M., Cormican, P., Furlong, S., Heron, E., Kenny, G., Fahey, C., Kelleher, E., Ennis, S., Tropea, D., Anney, R., Corvin, A. P., Donohoe, G., Gallagher, L., Gill, M., & Morris, D. W. (2014). Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. Molecular Psychiatry. https://doi.org/10.1038/mp.2013.127

Kerner, B. (2014). Genetics of bipolar disorder. In Application of Clinical Genetics. https://doi.org/10.2147/TACG.S39297

Ketter, T. A. (2010). Diagnostic features, prevalence, and impact of bipolar disorder. In The Journal of clinical psychiatry. https://doi.org/10.4088/JCP.8125tx11c

Khalid, M., Driessen, T. M., Lee, J. S., Tejwani, L., Rasool, A., Saqlain, M., Shiaq, P. A., Hanif, M., Nawaz, A., DeWan, A. T., Raja, G. K., & Lim, J. (2018). Association of CACNA1C with bipolar disorder among the Pakistani population. Gene. https://doi.org/10.1016/j.gene.2018.04.061

Kloiber, S., Czamara, D., Karbalai, N., Müller-Myhsok, B., Hennings, J., Holsboer, F., & Lucae, S. (2012). ANK3 and CACNA1C - Missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2012.04.017

Maletic, V., & Raison, C. (2014). Integrated Neurobiology of Bipolar Disorder. Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2014.00098

Miró, X., Meier, S., Dreisow, M. L., Frank, J., Strohmaier, J., Breuer, R., Schmäl, C., Albayram, Ö., Pardo-Olmedilla, M. T., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Reinhard, I., Bilkei-Gorzo, A., Cichon, S., Seidenbecher, C., Rietschel, M., Nöthen, M. M., & Zimmer, A. (2012). Studies in humans and mice implicate neurocan in the etiology of mania. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2012.11101585

Mühleisen, T. W., Leber, M., Schulze, T. G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Forstner, A. J., Schumacher, J., Breuer, R., Meier, S., Herms, S., Hoffmann, P., Lacour, A., Witt, S. H., Reif, A., Müller-Myhsok, B., Lucae, S., Maier, W., … Cichon, S. (2014). Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Communications. https://doi.org/10.1038/ncomms4339

Nurnberger, J. I., Berrettini, W., & Niculescu, A. B. (2016). Genetics of psychiatric disorders. In The Medical Basis of Psychiatry: Fourth Edition. https://doi.org/10.1007/978-1-4939-2528-5_29

Phillips, M. L., & Kupfer, D. J. (2013). Bipolar Disorder 2—Bipolar disorder diagnosis: Challenges and future directions. In The Lancet. https://doi.org/10.1016/S0140-6736(13)60989-7

Schultz, C. C., Mühleisen, T. W., Nenadic, I., Koch, K., Wagner, G., Schachtzabel, C., Siedek, F., Nöthen, M. M., Rietschel, M., Deufel, T., Kiehntopf, M., Cichon, S., Reichenbach, J. R., Sauer, H., & Schlösser, R. G. M. (2014). Common variation in NCAN, a risk factor for bipolar disorder and schizophrenia, influences local cortical folding in schizophrenia. Psychological Medicine. https://doi.org/10.1017/S0033291713001414

Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2017). Biological hypotheses and biomarkers of bipolar disorder. In Psychiatry and Clinical Neurosciences. https://doi.org/10.1111/pcn.12476

Simpson, J., Moriarty, G., Simpson, J. M., & Moriarty, G. L. (2015). Major Depression and Bipolar Disorder. In Multimodal Treatment of Acute Psychiatric Illness. https://doi.org/10.7312/columbia/9780231158831.003.0007

Strohmaier, J., Amelang, M., Hothorn, L. A., Witt, S. H., Nieratschker, V., Gerhard, D., Meier, S., Wüst, S., Frank, J., Loerbroks, A., Rietschel, M., Stürmer, T., & Schulze, T. G. (2013). The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.53

Szczepankiewicz, A. (2013). Evidence for single nucleotide polymorphisms and their association with bipolar disorder. In Neuropsychiatric Disease and Treatment. https://doi.org/10.2147/NDT.S28117

Valente, S. M., & Kennedy, B. L. (2010). End the bipolar tug-of-war. Nurse Practitioner. https://doi.org/10.1097/01.NPR.0000367933.64526.3e


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DOI: https://doi.org/10.26714/jkj.9.4.2021.911-918

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