Analysis of Factors Contributing to Treatment Success among Tuberculosis Patients: Cross-Sectional Study in Semarang, Indonesia

Nur Dian Rakhmawati; Muhamad Zakki Saefurrohim; Warsono Warsono

doi:10.26714/mki.6.1.2023.25-32

Analysis of Factors Contributing to Treatment Success among Tuberculosis Patients: Cross-Sectional Study in Semarang, Indonesia

Nur Dian Rakhmawati⁽¹⁾, Muhamad Zakki Saefurrohim⁽²⁾, Warsono Warsono^(3*)

(1) Dinas Kesehatan Kota Semarang, Jawa Tengah
(2) Program Pascasarjana Universitas Negeri Semarang
(3) Universitas Muhammadiyah Semarang
(*) Corresponding Author

Abstract

The success rate of TB treatment in Semarang City in 2021 will reach 81.15%. Patients recovered reached 20.20%. Complete Treatment reached 60.95%. Failed treatment 0.15%. Patients Died reached 5.96%. Treatment dropout (lost to follow-up) reached 12.43%. Not evaluated/moved reached 0.31%. This study aims to identify the factors that contribute to the success of TB treatment. This study used secondary data sourced from the Semarang City Tuberculosis Information System (SITB) which was recorded regularly during 2021-2022. 4,627 TB patients who had minimally complete variables were entered into univariate analysis, crosstabulation and binary logistic regression. The results of the multivariate analysis showed a joint relationship between the factors that contributed to the success of TB treatment. Negative DM Status (AOR = 1.33; CI95% = 1.092-1.619), Standard Treatment Status (AOR = 1.767; CI95% = 1.235-2.529), Type Puskesmas Health Facility (AOR=3.778; CI95%=3.114-4.582), New Patients Based on Previous Treatment History (AOR = 1.592; 95% CI = 1.263-2.007) with Nagelkerke R Square = 13.2%. TB treatment success strategies in Semarang City need to be improved.

Keywords

Determinant Factors; tuberculosis treatment; treatment success strategies

Full Text:

PDF

References

Chakaya J, Khan M, Ntoumi F, Aklillu E, Fatima R, Mwaba P, et al. Global Tuberculosis Report 2020–Reflections on the Global TB burden, treatment and prevention efforts. Int J Infect Dis. 2021;113:S7–12.

Chakaya J, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, et al. The WHO Global Tuberculosis 2021 Report–not so good news and turning the tide back to End TB. Int J Infect Dis. 2022;

Jeremiah C, Petersen E, Nantanda R, Mungai BN, Migliori GB, Amanullah F, et al. The WHO Global Tuberculosis 2021 Report - not so good news and turning the tide back to End TB. Int J Infect Dis IJID Off Publ Int Soc Infect Dis. 2022 Mar;

Chaisson RE, Frick M, Nahid P. The scientific response to TB–the other deadly global health emergency. Int J Tuberc Lung Dis. 2022;26(3):186.

Kemenkes RI. Profil Kesehatan Indonesia 2020. Kementrian Kesehat Republik Indones https//pusdatin kemkes go id/resources/download/pusdatin/profil-kesehatan-indonesia/Profil-Kesehatan-Indonesia-Tahun-2020 pdf. 2021;

Kemenkes RI. Profil Kesehatan Indonesia 2020. Kementrian Kesehatan Republik Indonesia. 2021. 139 p.

Andriyanto E, Wijayanti Subronto Y, Ida Safitri Laksanawati. Predictor Factors of Tuberculosis Treatment Success in Sleman Regency of Indonesia. Medica Hosp J Clin Med. 2022;9(2):187–93.

Okanurak K, Kitayaporn D, Akarasewi P. Factors contributing to treatment success among tuberculosis patients: A prospective cohort study in Bangkok. Int J Tuberc Lung Dis. 2008;12(10):1160–5.

Musaazi J, Kiragga AN, Castelnuovo B, Kambugu A, Bradley J, Rehman AM. Tuberculosis treatment success among rural and urban Ugandans living with HIV: a retrospective study. Public Heal action. 2017;7(2):100–9.

Jalal TMT, Abdullah S, Abd Wahab F, Dir S, Naing NN. Prevalence and factors associated with tuberculosis treatment success among TB/HIV co-infection in North-East Malaysia. Malaysian J Med Sci MJMS. 2017;24(6):75.

Ali MK, Karanja S, Karama M. Factors associated with tuberculosis treatment outcomes among tuberculosis patients attending tuberculosis treatment centres in 2016-2017 in Mogadishu, Somalia. Pan Afr Med J. 2017;28(1).

Jaiswal A, Singh V, Ogden JA, Porter JDH, Sharma PP, Sarin R, et al. Adherence to tuberculosis treatment: lessons from the urban setting of Delhi, India. Trop Med Int Heal. 2003;8(7):625–33.

Farmer P. Social scientists and the new tuberculosis. Soc Sci Med. 1997;44(3):347–58.

Liam CK, Lim KH, Wong CMM, Tang BG. Attitudes and knowledge of newly diagnosed tuberculosis patients regarding the disease, and factors affecting treatment compliance. Int J Tuberc Lung Dis. 1999;3(4):300–9.

Chauke GD, Nakwafila O, Chibi B, Sartorius B, Mashamba-Thompson T. Factors influencing poor medication adherence amongst patients with chronic disease in low-and-middle-income countries: A systematic scoping review. Heliyon. 2022;e09716.

Zhang H, Liang C, Zhang X, Yu H, Yan X, Wang L, et al. Factors influencing patient delay in individuals with obstructive sleep apnoea: a study based on an integrated model. Ann Med. 2022;54(1):2828–40.

Hulu PJ, Pane M, Sitorus MEJ, Manurung K, Sinaga J. Analysis of Drug User Compliance in Tuberculosis Patients on Therapy Successat Puskesmas Medan Deli Medan City year 2022. Sci Midwifery. 2022;10(5):4034–42.

Hill PC, Stevens W, Hill S, Bah J, Donkor SA, Jallow A, et al. Risk factors for defaulting from tuberculosis treatment: a prospective cohort study of 301 cases in the Gambia. Int J Tuberc Lung Dis. 2005;9(12):1349–54.

Chee CBE, Boudville IC, Chan SP, Zee YK, Wang YT. Patient and disease characteristics, and outcome of treatment defaulters from the Singapore TB control unit—a one-year retrospective survey. Int J Tuberc Lung Dis. 2000;4(6):496–503.

Andargie A, Molla A, Tadese F, Zewdie S. Lost to follow-up and associated factors among patients with drug resistant tuberculosis in Ethiopia: A systematic review and meta-analysis. PLoS One. 2021;16(3):e0248687.

Viswanathan AA, Gawde NC. Effect of type II diabetes mellitus on treatment outcomes of tuberculosis. Lung India Off Organ Indian Chest Soc. 2014;31(3):244.

Leung CC, Yew WW, Mok TYW, Lau KS, Wong CF, Chau CH, et al. Effects of diabetes mellitus on the clinical presentation and treatment response in tuberculosis. Respirology. 2017;22(6):1225–32.

Sulaiman SAS, Khan AH, Ahmad N, Iqubal MS, Muttalif AR, Hassali MA. Impact of diabetes mellitus on treatment outcomes of tuberculosis patients in tertiary care setup. Am J Med Sci. 2013;345(4):321–5.

Eshetie S, Gizachew M, Alebel A, van Soolingen D. Tuberculosis treatment outcomes in Ethiopia from 2003 to 2016, and impact of HIV co-infection and prior drug exposure: A systematic review and meta-analysis. PLoS One. 2018;13(3):e0194675.

Tola A, Mishore KM, Ayele Y, Mekuria AN, Legese N. Treatment outcome of tuberculosis and associated factors among TB-HIV Co-infected patients at public hospitals of Harar town, eastern Ethiopia. A five-year retrospective study. BMC Public Health. 2019;19(1):1–12.

Finlay A, Lancaster J, Holtz TH, Weyer K, Miranda A, van der Walt M. Patient-and provider-level risk factors associated with default from tuberculosis treatment, South Africa, 2002: a case-control study. BMC Public Health. 2012;12(1):1–12.