Maternal interleukin-6 and prostaglandin levels post-regiosacral counter-pressure as pain therapy due to uterine contractions

Sri Rejeki; Achmad Solichan; Fitri Nuroini

doi:10.26714/mki.4.4.2021.291-297

Maternal interleukin-6 and prostaglandin levels post-regiosacral counter-pressure as pain therapy due to uterine contractions

Sri Rejeki^(1*), Achmad Solichan⁽²⁾, Fitri Nuroini⁽³⁾

(1) Universitas Muhammadiyah Semarang
(2) Universitas Muhammadiyah Semarang
(3) Universitas Muhammadiyah Semarang
(*) Corresponding Author

Abstract

Pain is a physiological condition that is generally experienced by almost all mothers in labor or pain during menstruation (dysmenorrhea). Pain causes tachycardia in the mother, increased oxygen consumption, lactic (lactic) acid production, hyperventilation with a risk of respiratory alkalosis, and increased skeletal muscle tension. Regiosarcal Counter Pressure is an effective therapy to reduce pain due to uterine contractions. Based on research that has been done, Regiosarcal counter-pressure therapy can reduce pain levels and has also been shown to slightly reduce prostaglandin (PGE-2) levels in an insignificant amount. Changes in PGE-2 are suspected to have an impact on the stimulant hormone Interleukin-6 (IL-6). This study aims to determine the levels of IL-6 and prostaglandins in the first stage of labor. The research method used quasi-experimental, with inclusion criteria of first-stage labor, no pelvic abnormalities and other abnormalities that hindered the process of vaginal delivery, primiparas, singleton pregnancies, the location of the head did not receive painkillers. The results obtained 25 respondents with an average age of 23.72 (± 2.89) years, the average concentration of IL-6 before therapy was 185.159 (± 3.76) pg/ml and the mean after therapy was 180.782 (± 22.05) pg. /ml, the mean concentration of PGE2 before treatment was 223.521 (± 72.73) pg/ml and the mean after treatment was 179.873 (± 110.61) pg/ml. Administration of regiosacral counter-pressure therapy did not significantly reduce the levels of the hormone IL-6 and prostaglandins in women who experienced uterine contractions.

Keywords

Regiosacral Counter-pressure; Interleukin 6; Prostaglandin E 2; uterine contractions

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References

Ayu NGM, Supliyani E. Karakteristik Ibu Bersalin Kaitannya Dengan Intensitas Nyeri Persalinan Kala 1 Di Kota Bogor. J Kebidanan Malahayati 2017;3:204–10.

Arikhman N. Penurunan Intensitas Nyeri Persalinan Fase Aktif Kala I Melalui Terapi Musik Instrumental. J Keperawatan Indones 2010;13:32–6.

Marwa AR, Sumarah S, Maryani T. Perbedaan Skala Nyeri Kala I Dan Durasi Kala II Persalinan pada Primigravida dengan Senam dan Yoga Kehamilan. vol. 11. 2017.

Tanvisut R, Traisrisilp K, Tongsong T. Efficacy of aromatherapy for reducing pain during labor: a randomized controlled trial. Arch Gynecol Obstet 2018;297:1145–50. https://doi.org/10.1007/s00404-018-4700-1.

Bobak I., et all. Maternity Nursing. California: Mosby; 2005.

Tzeng YL, Yang YL, Kuo PC, Lin YC, Chen SL. Pain, anxiety, and fatigue during labor: A prospective, repeated measures study. J Nurs Res 2017;25:59–67. https://doi.org/10.1097/jnr.0000000000000165.

Chuang C-H, Chen P-C, Lee CS, Chen C-H, Tu Y-K, Wu S-C. Music intervention for pain and anxiety management of the primiparous women during labour: A systematic review and meta-analysis. J Adv Nurs 2019;75:723–33. https://doi.org/10.1111/jan.13871.

Smith CA, Levett KM, Collins CT, Dahlen HG, Ee CC, Suganuma M. Massage, reflexology and other manual methods for pain management in labour. Cochrane Database Syst Rev 2018;28. https://doi.org/10.1002/14651858.CD009290.pub3.

Rejeki RM. Bagus SI. Tingkat Nyeri Persalinan Kala I Persalinan Melalui Terapi Alat Mekanik Manual Regio Sakralis. Pros Semin Nas 2012.

Stillerman E. A midwife’s touch 2008.

Rejeki S. Praktik counter -pressure oleh suami pada isteri dalam. Muswil IPEMI Jateng, 2016, p. 125–30.

Rejeki, Sri , Ullfa Nurulita RK. Tingkat nyeri pinggang kala i persalinan melalui teknik n.d.;1:124–33.

Rilyani, Arianti L, Wiagi. Pengaruh Counter Pressure Terhadap Skala Nyeri Persalinan Di Rumah Sakit Daerah May. Jend. Hm. Ryacudu Kotabumi Lampung Utara Tahun 2017. J Holist Healthc 2017;11:257–64.

Rejeki S, Soejonoes A, Soenarjo, Husni A. Tingkat Nyeri Dan Prostaglandin-E2 Pada Ibu Inpartu Kala I Dengan Tindakan Counter-Pressure. J Ners 2014;9:111–7.

Jesica F, Friadi A. Hubungan kadar kortisol dan prostaglandin maternal. J Ilmu Keperawatan Dan Kebidanan 2019;10:21–9.

Manuaba IB., Manuaba IAC, Manuaba IBGF. Pengantar Kuliah Obstetri. Jakarta: EGC; 2007.

Behrman R, ButlerA, editors. Preterm birth: causes, consequences, and prevention. Washington DC: The National Academic Press; 2007.

Unfried G, Böcskör S, Endler G, Nagele F, Huber JC, Tempfer CB. A polymorphism of the interleukin‐6 gene promoter and idiopathic recurrent miscarriage. Hum Reprod 2003;18:267–70.

Rejeki S. Gambaran kadar PG-E 2 dan Kadar Interleukin-6 saat nyeri persalinan melalui metode. Pros. Konf. Nas. II PPNI Jawa Teng. 2014, vol. 2, 2014, p. 6–13.

Barnhart K, Dunsmoor-su R, Coutifaris C. Effect of endometriosis on in vitro fertilization 2002;77.

Resnik R, Creasy RK, Iams JD, Lockwood CJ, Moore T, Greene MF. Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book. 6th ed. Philadelphia: Saunders Elsebier; 2009.

Aurora Espejel Núñez, Enríquez MG, Díaz GB, González EG, Montoya JB, Ortega FV. Interleukin-6 levels changes in cervicovaginal exudates in labor evolution. Ginecol Obs Mex 2008;76:3–8.

Kawilarang S, Suwiyoga IK, Suwardewa TG. Elevated Serum Ferritin and Interleukin-6 Level as the Risk Factor in Preterm Labor. Indones J Obstet Gynecol 2019;7. https://doi.org/https://doi.org/10.32771/inajog.v7i2.1002.

Susianto IA, Suharsono, Hadijono S. Kadar TNF-(, IL-6 dan Trofoblas pada Preeklampsia-Eklampsia. Media Med Indones 2009;43.

Cunningham FL, KJ B, Hauth S, Rouse J, DJ. Spong C. William Obstetrics 24th edition. Jakarta: EGC; 2014.

Habersaat S, Borghini A, Faure, N. Nessi J, Guex, MF.Pierrehumbert B e. al. Emotional and neuroendocrine regulation invery preterm and full-term infants. Eur J Dev Psychol 2013;10:691–706.

Guo Q, Li J, Zhong L, Cai H, Wang H, Yan H, et al. Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1β derived from periaortic lymph nodes lead to abortion. Mol Hum Reprod 2019;25:825–37. https://doi.org/10.1093/molehr/gaz058.

Hirsbrunner G, Eicher R, Küpfer U, Burkhardt H, Steiner A. Effect of different doses of prostaglandin E2 on intrauterine pressure and uterine motility during diestrus in experimental cows. Theriogenology 2000;54:291–303. https://doi.org/10.1016/s0093-691x(00)00349-6.

Chin-Smith, C E, Slater DM, Johnson MR, Al. E. STIM and Oral isoform expression in pregnant human myometrium : a potential role in calcium signaling during pregnancy. Front Physiol 2014;5.

Dawood M. Primary Dysmenorrhea Advances in Pathogenesis and Management. J Obstet Gynaecol 2006;108.

Bailie CA l, Vedernikov YP, Saade GR, Garfield RE. Prostaglandin-induced activation of uterine contractility in pregnant rats does not involve potassium channels. Am J Obs Gynecol 2002;186:453–7. https://doi.org/10.1067/mob.2002.120484.

Giuseppe Chiossi, Costantine MM, Bytautiene E, Kechichian T, Hankins GD V, Sbrana E, et al. The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure. Am J Perinatol 2012;29:615–22. https://doi.org/10.1055/s-0032-1311986.