Perbedaan NLR, PLR dan CRP pada Pasien Covid-19 Di ICU dengan Non ICU

Melisa Ratnawati Tjandra(1*), Purwanto Adipireno(2)


(1) Fakultas Kedokteran Universitas Diponegoro
(2) Fakultas Kedokteran Universitas Diponegoro
(*) Corresponding Author

Abstract


Latar Belakang: COVID-19 merupakan penyakit menular yang akibatkan oleh infeksi SARS-CoV-2. Gejala klinis bervariasi dari penyakit seperti flu ringan sampai berat hingga mengarah ke ARDS. Parameter inflamasi seperti Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) dan C-Reactive Protein (CRP) adalah penanda prognosis keparahan dan kematian COVID-19.

Metode: Mulai bulan Juni hingga September 2021, 91 pasien yang terinfeksi COVID-19 di Rumah Sakit Dr. Kariadi dilakukan pendataan dengan pen-dekatan cross sectional mengenai karakteristik umum, analisis darah lengkap, kadar NLR, PLR dan CRP dari rekam medis pasien di ICU dan non-ICU menggunakan independent t-test pada tahap observasi analitik. Hasil uji statistik bermakna apabila p

Hasil: Partisipan berasal dari dua kelompok, 46 pasien dirawat di ICU dan 45 pasien dirawat di non-ICU. Rerata usia pasien dengan infeksi COVID-19 di ICU (52,78 ± 7,41) lebih tua dari pasien di non-ICU (47,09 ± 9,86). Nilai PLR (29.089,63 ± 16.597,39), NLR (8.9 ± 4.37) dan CRP (12.15 ± 6.75 mg/dL) secara signifikan (p=0,000) lebih tinggi pada kelompok ICU.

Kesimpulan: NLR, PLR, dan CRP secara signifikan lebih tinggi pada pasien COVID-19 di ICU. Parameter ini dapat membantu mengidentifikasi keparahan infeksi dan risiko kematian COVID-19.


Keywords


COVID-19, NLR, PLR, CRP, ICU

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References


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DOI: https://doi.org/10.26714/medart.4.2.2022.83-89

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Jl. Kedungmundu Raya No. 18, Semarang, Indonesia
Email: medica.arteriana@unimus.ac.id