Analisis Nilai Indeks Trombosit Dan Rasio Trombosit Limfosit Sebagai Penanda Inflamasi Glomerulus Pada Penderita Hipertensi Berbagai Derajat

Nelly Tolla Taggara




Background :

Hypertension is a major risk factor for early death and cardiovascular disease (CVD), which causes at least 1.1 million deaths per year in the world. Hypertension is also called The Silent Killer because it is often found without symptoms, which if left untreated and treated will cause complications such as stroke, heart and blood vessel disease, kidney disorders and others which can ultimately lead to disability or death. Endothelial dysfunction indirectly affects platelet dysfunction which can be assessed based on platelet index and platelet lymphocyte ratio. 2,6,7

Method :

170 Patients with hypertension are grouped into hypertensive stage groups 1, 2 and 3. Platelet index (MPV, PDW and PCT) and lymphocyte platelet ratio are calculated based on the results of routine blood tests. Data distribution was tested by Kolmogrov-Smirnov and analyzed with the corresponding data test.


Platelet index namely MPV in hypertensive patients was significantly different in each degree of hypertension, grade 1 (8.92 ± 1.23), degree 2 (8.99 ± 1.63) and degree 3 (11.2 ± 4.29) with a p value = 0.003. There is a weak correlation between MPV and serum creatinine ureum levels. However, PDW and RTL values only correlate with creatinine.


There are differences in the value of MPV in patients with hypertension of various degrees. There is a correlation between the values of MPV, PDW and RTL and creatinine which indicate inflammation of the glomerulus.







Hypertension, platelet index (MPV, PDW and PCT) and lymphocyte platelet ratio

Full Text:



Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI). 2015. Pedoman Tatalaksana Hipertensi pada Penyakit Kardiovaskular. Edisi I. Jakarta: PERKI.

Rilantono, L.I. 2016. Penyakit Kardiovaskular. Fakultas Kedokteran Universitas Indonesia: Jakarta.

Yogiantoro Mohammad. Pendekatan Klinis Hipertensi. Dalam : Buku Ajar Ilmu Penyakit Dalam. Edisi VI. Jakarta.Interna Publishing. 2015. Hal 2259-83

World Health Organization (WHO). 2013. Calls for Intensiified Efforts to Prevent and Control Hypertension, (Online), ( workforcealiance/media/news/, diakses 16 Februari 2018).

Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS). 2013. Available from:

James PA, Oparil S, Carter BI, et al. Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the eighth Joint National Committee (JNC 8). 2014. Available from Center for Health Statistic. National Health and Nutrition Examination Survey (NHANES). December 2017 . Available from: data/factsheets/factsheet_nhanes.pdf

Osuji C. U. Nwaneli. Onwubere B. J. Onwubuya E. I..Ahaneku G. I. Renal Function in Patients with Hypertension Associated Congestive Cardiac Failure Seen in a Tertiary Hospital. July 2012 Available from :

McLaughlin, K., Zhang, J., Lye, S. J., Parker, J. D., & Kingdom, J. C. (2018). Phenotypes of pregnant women who subsequently develop hypertension in pregnancy. Journal of the American Heart Association, 7(14), e009595.

Surgit O. Pusuroglu H. Erturk M. et all. Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives. July2014.Available from: https:// www. ncbi. nlm. nih. gov/ pmc/articles/PMC4494555/.

Kocyigit I, Eroglu E, Unal A, Sipahioglu MH, Tokgoz B, Oymak O et al. Role of neutrophil/lymphocyte ratio in prediction of disease progression in patients with stage–4 chronic kidney disease. Journal Nephrology 2013; 26(02): 358-65

Joshi Basant, Singh Sageeta, Pandey Suman. A study of serum urea, creatinine and proteinuria in hypertensive patients. October, 2016. Available from :

Kusumawaty Y, Nur Hidayat, Eko Ginanjar, Hubungan Jenis Kelamin dan Hipertensi Pada Lansia di Wilayah Kerja Puskesmas Lakbok Kabupaten Ciamis, Available from : Https :// vol.16 N0.2 : July 2016

Surgit O, Pusuroglu H, Erturk M, et al. Assessment of mean platelet volume in patients with resistant hypertension, controlled hypertension and normotensives. Eurasian J Med 2015;47:79–84

Giovanetti TV, do Nascimento AJ, de Paula JP. Platelet indices: laboratory and clinical applications. Rev Bras Hematol Hemoter 2011; 33:164–165

Yang K, Lixin T, Gehendra M, Yan Yan, Kai Cao, et al. An association of platelet indices with blood pressure in Beijing adults, Applying quadratic inference function for a longitudinal study. Medicine (Baltimore). 2016 Sep; 95(39): e4964.

Article Metrics

Abstract view : 191 times
PDF - 14 times



  • There are currently no refbacks.


Faculty of Medicine, Universitas Muhammadiyah Semarang
Jl. Kedungmundu Raya No. 18, Semarang, Indonesia