Moringa Leaf Nanoparticles as an Alternatives to Improve Hemoglobin and Hematocrit Levels in Stunting Toddlers

Sherly Dwi Gustiya(1*), Suharyo Hadisaputro(2), Sri Sumarni(3)


(1) Poltekkes Kemenkes Semarang
(2) Polkkes Kemenkes Semarang
(3) Poltekkes Kemenkes Semarang
(*) Corresponding Author

Abstract


Background: Stunting is a condition of short toddlers is a discrepancy between height for age which is measured based on the z-score <-2 SD. The highest prevalence of stunting in Central Java was in Magelang Districts by 37.6%. Aims: The objective of this study is to prove that consuming Moringa Oleifera leaf nanoparticles influences the increase in hemoglobin and hematocrit levels in stunting toddlers. Method: This is a quasy experimental study with pretest and posttest with control group design. The number of samples were 40 stunting toddlers who measured based on the z score <-2 SD. Those were divided into treatment groups (Moringa Oleifera leaf nanoparticles dose of 65 mg/day and supplementary feeding) and control groups (supplementary feeding) each group consisted from 20 toddlers. Interventions were given for 21 days. Examination of hemoglobin and hematocrit levels using the Hematology Analyzer method. Results: The hemoglobin level increased significantly from 11,365 g/dL to 12,610 g/dL with a value of p=0.001 in the intervention group. Moreover, hemoglobin level in the control group a slightly increased from 11.455 g/dL to 11.610 g/dL with a value of p=0.648. Hematocrit levels increased significantly (p=0.001) from 35.810% to 43.575% in the intervention group. Hematocrit level also improved slightly in the control group from 31.330% to 31.690%. However, it was not significantly with p=0.455. Conclusion: It is Proved that Moringa Oleifera leaf nanoparticles improves hemoglobin and hematocrit levels in stunting toddlers. The increase hemoglobin and hematocrit levels are greater in the intervention group rather than the control group.


Keywords


Moringa Oleifera leaf nanoparticle, hemoglobin levels, hematocrit levels, stunting

Full Text:

PDF

References


Adedapo, A. A., Mogbojuri, O. M., & Emikpe, B. O. (2009). Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. Journal of Medicinal Plants Research, 3(8), 586–591.

Adegbite, O. A., Omolaso, B., Seriki, S. A., & Shatima, C. (2016). Effects of Moringa Oleifera Leaves on Hematological Indices in Humans. Annals of Hematology & Oncology, 3(8), 1–7.

Adelasanti, A. N. dan L. R. R. (2018). Hubungan Antara Kepatuhan Konsumsi Pemberian Makanan Tambahan Balita dengan Perubahan Status Gizi Balita di Puskesmas Pucangsawit Surakarta. 1(2), 92–100.

Adriani, M. dan B. W. (2016). Pengantar Gizi Masyarakat (Cetakan ke). Kencana.

Almatsier, S. (2010). Prinsip Dasar Ilmu Gizi. PT Gramedia Pustaka Utama.

Arya, A. K., Kumar, P., Midha, T., & Singh, M. (2017). Hematological profile of children with severe acute malnutrition: a tertiary care centre experience. International Journal of Contemporary Pediatrics, 4(5), 1577.

Ayoya, M. A., Ngnie-Teta, I., Séraphin, M. N., Mamadoultaibou, A., Boldon, E., Saint-Fleur, J. E., Koo, L., & Bernard, S. (2013). Prevalence and risk factors of anemia among children 6-59 months old in Haiti. Anemia, 2013, 2–5.

Berry, S. B., Fernandes, S. C., Rajaratnam, A., Dechiara, N. S., & Mace, C. R. (2016). Measurement of the hematocrit using paper-based microfluidic devices. Lab on a Chip, 16(19), 3689–3694.

Bloch, M., British Department for Education, British Education Funding Agency, Dockreill, J. E., Shield, B. M., Nelson, P., Soli, S., Shendell, D. G., Ana, G. R. E. E., Brown, G. E., Sridhar, M. K. C., Pujol, S., Levain, J. P., Houot, H., Petit, R., Berthillier, M., Defrance, J., Lardies, J., Masselot, C., … Fingerhut, M. (2013). PMK no.75 TENTANG ANGKA KECUKUPAN GIZI YANG DIANJURKAN BAGI BANGSA INDONESIA. 2.

Doria, E. (2017). Total Antioxidant Capacity, Antimicrobial Activity and Preliminary Analysis of Some Nutritional Compounds in Moringa Oleifera preparations. International Journal of Food and Nutritional Science, 4(1), 1–7.

Estiyani, A., Suwondo, A., Rahayu, S., Hadisaputro, S., Widyawati, M. N., & Susiloretni, K. A. (2017). the Effect of Moringa Oleifera Leaves on Change in Blood Profile in Postpartum Mothers. Belitung Nursing Journal, 3(3), 191–197.

G. Barragan-Ibanesz, A. santoyo-S. and C. O. R.-P. (2016). Besi defisiensi anemia. 79(2), 88–97.

Guyton A.C and John E. Hall. (2011). MEDICAL PHYSIOLOGY (13Th Editi). Elsevier.

Hamzah, H., & Yusuf, N. R. (2019). Analisis Kandungan Zat besi (Fe) Pada Daun Kelor (Moringa oleifera Lam.) Yang Tumbuh dengan Ketinggian Berbeda di Daerah Kota Baubau. Indo. J. Chem. Res., 6(2), 30–35.

Hendrayati dan Ramlan Asbar. (2018). Faktor Determinan Kejadian Stunting pada Balita Usia 12 sampai 60 Bulan. Media Gizi Pangan, 25.

Herawati, A. N., Palupi, N. S., Andarwulan, N., & Efriwati. (2018). Contribution of Iron and Vitamin C Intake To Iron Deficiency Anemia Status. 41(2), 65–76.

Ikatan Dokter Anak Indonesia. (2011). Buku ajar Nutrisi Pediatrik dan Penyakit Metabolik. Badan Penerbit IDAI.

Kementerian Kesehatan Republik Indonesia. (2017). Hasil Pemantauan Status Gizi ( Psg ) Tahun 2017. Direktorat Gizi Masyarakat.

Kementerian Kesehatan RI. (2018a). Profil Kesehatan Indonesia Tahun 2017 (pp. 107–108).

Kementerian Kesehatan RI. (2018b). Situasi Balita Pendek (Stunting) di Indonesia. Journal of Molecular Biology, 301(5), 1163–1178.

Lima, G. L. (2011). Characterization and Conservatin of the Ovarian Prenatal Follicles’ Population of Callared Peccaries.

Losong, N. H. F., & Adriani, M. (2017). Perbedaan Kadar Hemoglobin, Asupan Zat Besi, dan Zinc pada Balita Stunting dan Non Stunting. Amerta Nutrition, 1(2), 117–123.

Mahameru Pradanti, C., Sulistya, H. K., & Studi Gizi Fakultas Ilmu Keperawatan dan Kesehatan, P. (2015). Hubungan Asupan Zat Besi (Fe) dan Vitamin C dengan Kadar Hemoglobin pada Siswi Kelas VIII SMP Negeri 3 Brebes. Jurnal.Unimus.Ac.Id, 4(1), 24–29.

Meilanie, A. D. R. (2019). Perbedaan Nilai Hematokrit Metode Mikrohematokrit Dan Metode Otomatis Pada Pasien Demam Berdarah Dengue Dengan Hemokonsentrasi. Journal of Vocational Health Studies, 03, 67–71.

Nismawardah, S. H. dan R. S. E. P. (2019). The effect of Moringa oleifera leaves nanoparticles extract on hematology profile in breast cancer patients of chemotherapy programs. 18–24.

Osman, H. M., Shayoub, M. E., Babiker, E. M., Osman, B., & Elhassan, A. M. (2012). Effect of Ethanolic Leaf Extract of Moringa oleifera on Aluminum-induced Anemia in White Albino Rats. Jordan Journal of Biological Sciences, 5(4), 255–260.

Pusat Data dan Informasi Kemenkes RI. (2016). Infodatin: Situasi Balita Pendek. ACM SIGAPL APL Quote Quad, 29(2), 63–76.

Roziko, I. O. dan N. (2016). Hubungan Asupan Protein, Zat Besi, Vitamin C Dan Seng Dengan Kadar Hemoglobin Pada Balita Stunting. Journal of Nutrition College, 5(4), 419–427.

Srikanth, V. S., Mangala, S., & Subrahmanyam, G. (2014). Improvement of Protein Energy Malnutrition by Nutritional Intervention with Moringa Oleifera among Anganwadi Children in Rural Area in Bangalore , India. International Journal of Scientifi c Study, 2(1), 32–35.

Sundari, E., & Nuryanto, N. (2016). HUBUNGAN ASUPAN PROTEIN, SENG, ZAT BESI, DAN RIWAYAT PENYAKIT INFEKSI DENGAN Z-SCORE TB/U PADA BALITA. Journal of Nutrition College, 5(4), 520–529.

Suzana, D., Suyatna, F. D., Azizahwati, Andrajati, R., Sari, S. P., & Mun’im, A. (2017). Effect of moringa oleifera leaves extract against hematology and blood biochemical value of patients with iron deficiency anemia. Journal of Young Pharmacists, 9(1), S79–S84.

Syahrial, S., Rimbawan, R., Damayanthi, E., Astuti, D. A., & Suptijah, P. (2019). Pengaruh pemberian nano daun kelor (moringa oleifera) terhadap kadar mineral serum dan tulang pada tikus sprague dawley jantan tumbuh. Jurnal Gizi Indonesia, 7(2), 114.

Waroh, Y. K. (2019). Pemberian Makanan Tambahan Sebagai Upaya Penanganan Stunting. XI(1), 47–54.


Article Metrics

Abstract view : 458 times
PDF - 1 times

DOI: https://doi.org/10.26714/jk.11.2.2022.157-166

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 Jurnal Kebidanan

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


JURNAL KEBIDANAN

Program Studi Kebidanan
Fakultas Ilmu Keperawatan dan Kesehatan
Universitas Muhammadiyah Semarang, Indonesia
NRC Building, 2nd FLoor
Jl. Kedungmundu Raya No. 18, Semarang
Tlp. +6224-76740288, Fax. +6224-76740287