Effect of Mackerel Oil During Pregnancy on Synapsin Expression in Newborn Rattus Novergius Cerebrum

Siti Nur Kholifah(1*), Widjiati Widjiati(2), Hermanto Tri Joewono(3), Ali Medina(4), Mikra Latisfian(5)


(1) Master of Reproductive Health, Faculty of Medicine, Airlangga University, Indonesia
(2) Department of Embryology, Faculty of Veterinary Medicine, Airlangga University, Indonesia
(3) Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, Indonesia
(4) Master of Reproductive Health, Faculty of Medicine, Airlangga University, Indonesia
(5) Master of Reproductive Health, Faculty of Medicine, Airlangga University, Indonesia
(*) Corresponding Author

Abstract


The increase in the number of cells indicates a good synapse function, so that it can be linked to human intelligence. The rapid rate of synaptogenesis, myelination occurs in the first 1000 days of life. The public has not realized the importance of nutrition during pregnancy which contributes to the intelligence of the baby that will be born later. One of them is mackerel oil which contains omega 3. This study aims to analyze the effect of mackerel oil during pregnancy on synapsin expression in the cerebrum. This type of research is true experimental with a posttest-only control group design. The research samples were 30 pregnant Rattus norvegicus mothers aged 2-3 months. The 3 groups were randomly divided namely the control group (K1), the mackerel fish oil treatment group (K2), and the treatment group who were given omega-3 supplements (K3). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. ANOVA test results on synapsin expression in the cerebrum showed that there was a significant difference with a p-value of 0.000. Synapsin expression in the cerebrum of newborn Rattus norvegicus which was given mackerel oil in the mother of Rattus norvegicus during pregnancy showed higher results than other groups.


Keywords


cerebrum; mackerel oil; synapsin

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References


Adjepong, M., Pickens, C. A., Jain, R., Harris, W. S., Annan, R. A., & Fenton, J. I. (2018). Association of whole blood n-6 fatty acids with stunting in 2-to-6-year-old Northern Ghanaian children: A cross-sectional study. PloS One, 13(3), e0193301.

Bloem, M. W., de Pee, S., Hop, L. T., Khan, N. C., Laillou, A., Minarto, Moench-Pfanner, R., Soekarjo, D., Soekirman, Solon, J. A., Theary, C., & Wasantwisut, E. (2013). Key strategies to further reduce stunting in Southeast Asia: lessons from the ASEAN countries workshop. Food and Nutrition Bulletin, 34(2 Suppl), 8–16. https://doi.org/10.1177/15648265130342s103

Branca, F., & Ferrari, M. (2002). Impact of micronutrient deficiencies on growth: the stunting syndrome. Annals of Nutrition and Metabolism, 46(Suppl. 1), 8–17.

Burciu, R. G., Reinold, J., Rabe, K., Wondzinski, E., Siebler, M., Müller, O., Theysohn, N., Gerwig, M., Donchin, O., & Timmann, D. (2014). Structural correlates of motor adaptation deficits in patients with acute focal lesions of the cerebellum. Experimental Brain Research, 232, 2847–2857.

Desai, A., Kevala, K., & Kim, H.-Y. (2014). Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. PloS One, 9(1), e86472.

Evergren, E., Benfenati, F., & Shupliakov, O. (2007). The synapsin cycle: a view from the synaptic endocytic zone. Journal of Neuroscience Research, 85(12), 2648–2656.

Fitriyani, F., Aisyah, R. D., & Suparni, S. (2017). IbM Pemberian Nutrisi Brain Booster pada Ibu Hamil. Prosiding Seminar Nasional & Internasional, 1(1).

Fornasiero, E. F., Bonanomi, D., Benfenati, F., & Valtorta, F. (2010). The role of synapsins in neuronal development. Cellular and Molecular Life Sciences, 67(9), 1383–1396. https://doi.org/10.1007/s00018-009-0227-8

Joewono, H. T. (2019). Bersujud Dalam Rahim 2 Mencerdaskan Janin Sejak Dalam Rahim Dengan Kombinasi Stimulasi 11-14 Musik Karya Mozart Dan Nutrisi. Global Persada Press 2013.

Joewono, H. T. (2020). The Evidence For The Influence of Musical Compositions During Pregnancy to the Structure and Functions of the Offsprings’ Brain. Majalah Obstetri Dan Ginekologi, 28(1), 44–51.

Latupeirissa, L., & Rumahlatu, D. (2016). Pengaruh Cara Pemasakan dengan Waktu yang Berbeda terhadap Komposisi Asam Lemak Omega-3 Ikan Lema (Rastrelliger kanagurta). Majalah BIAM, 12(2), 1–7.

Li, C., Zhu, N., Zeng, L., Dang, S., Zhou, J., & Yan, H. (2016). Effect of prenatal and postnatal malnutrition on intellectual functioning in early school-aged children in rural western China. Medicine, 95(31).

Lutter, C. K., Chaparro, C. M., & Muñoz, S. (2011). Progress towards Millennium Development Goal 1 in Latin America and the Caribbean: the importance of the choice of indicator for undernutrition. Bulletin of the World Health Organization, 89, 22–30.

Lynn, R. (2009). What has caused the Flynn effect? Secular increases in the Development Quotients of infants. Intelligence, 37(1), 16–24.

Mitra, M. (2015). Permasalahan Anak Pendek (Stunting) dan Intervensi untuk Mencegah Terjadinya Stunting (Suatu Kajian Kepustakaan). Jurnal Kesehatan Komunitas, 2(6), 254–261.

Norouzkhani, N., Karimi, A. G., Badami, N., Jalalifar, E., Mahmoudvand, B., Ansari, A., Pakrou Sariyarighan, N., Alijanzadeh, D., Aghakhani, S., Shayestehmehr, R., Arzaghi, M., Sheikh, Z., Salami, Y., Marabi, M. H., Abdi, A., & Deravi, N. (2022). From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders. Frontiers in Pharmacology, 13(November), 1–30. https://doi.org/10.3389/fphar.2022.960037

Prahadina, V. D., Boer, M., & Fahrudin, A. (2015). Sumberdaya ikan kembung (Rastrelliger kanagurta Cuvier 1817) di perairan selat sunda yang didaratkan di PPP Labuan, Banten (Resources of Indian Mackerel (Rastrelliger kanagurta Cuvier 1817) in Sunda Strait Water that Landed on PPP Labuan, Banten). Marine Fisheries: Journal of Marine Fisheries Technology and Management, 6(2), 169–175.

RI, K. K. (2019). Kebijakan dan Strategi Penanggulangan Stunting di Indonesia. https://persi.or.id/images/2019/data/FINAL_PAPARAN_PERSI_22_FEB_2019_Ir._Doddy.pdf.

Riskesdas. (2013). Penyajian Pokok-pokok Hasil Riset Kesehatan Dasar 2013, Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. http://kesga.kemkes.go.id/images/pedoman/Data Riskesdas 2013.pdf.

Simopoulos, A. P. (2016). Nutrients 2016, 8, 128. DOI.

Siriwardhana, N., Kalupahana, N. S., & Moustaid-Moussa, N. (2012). Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid. Advances in Food and Nutrition Research, 65, 211–222.

Unicef. (2013). Improving Child Nutrition The Achievable Imperative for Global Progress. New York: Unicef. https://www.unicef.org/publications/files/Nutrition_Report_final_lo_res_8_April.pdf.

Weiser, M., Butt, C. M., & Mohajeri, M. H. (n.d.). Docosahexaenoic acid and cognition throughout the lifespan. Nutrients. 2016; 8 (99). PUBMED.

Wingate D.S. (2019). Healing Brain Injury Naturally. DWS Health Services. https://www.google.co.id/search?tbm=bks&hl=id&q=healingbraininjurynaturally.

Woldeamanuel, G. G., Geta, T. G., Mohammed, T. P., Shuba, M. B., & Bafa, T. A. (2019). Effect of nutritional status of pregnant women on birth weight of newborns at Butajira Referral Hospital, Butajira, Ethiopia. SAGE Open Medicine, 7. https://doi.org/10.1177/2050312119827096


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DOI: https://doi.org/10.26714/jk.12.2.2023.169-176

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