Risk Factors Associated with the Incidence of Ovarian Cancer

Auliana Rochsas(1*), Listyaning Eko Martanti(2), Runjati Runjati(3)


(1) Poltekkes Kemenkes Semarang, Indonesia
(2) Poltekkes Kemenkes Semarang, Indonesia
(3) Poltekkes Kemenkes Semarang, Indonesia
(*) Corresponding Author

Abstract


Ovarian cancer is the biggest malignancy problem in female reproduction today. Dr. Hospital H. Abdul Moeloek as a referral center hospital in Lampung province has data that ovarian cancer is the most gynecological cancer with cases that have continued to increase over the past 3 years. The purpose of this study was to determine the risk factors associated with the incidence of ovarian cancer in RSUD Dr. H. Abdul Moeloek Lampung Province. This type of research is quantitative with a case-control design. The population was all patients treated in the gynecology room with 70 case samples taken using total sampling and 70 control samples using simple random sampling. The results showed that the factors related to the incidence of ovarian cancer in RSUD Dr. H. Abdul Moeloek included age (p-value = 0.001 and OR = 13.5 with 95% CI = 6.01-30.31), history of breastfeeding (p-value = 0.009 and OR = 2.684 with 95% CI = 1.326 -5.432), and a history of contraception (p-value = 0.001 and OR = 3.882 with 95% CI = 1.855-8.126). While the age of menarche and parity has no relationship with the incidence of ovarian cancer. From the research results expected, the high incidence of ovarian cancer in Lampung province can be socialized properly in society, so that people understand and can prevent ovarian cancer early.


Keywords


age; breastfeeding; contraception

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References


Adisasmita, A., Maryani, D., & Dwipoyono, B. (2016). The Relationship between Breastfeeding and the Risk of Ovarian Cancer. Indonesian Journal of Cancer, 10(3), 93–102.

Arthur, R., Brasky, TM, Crane, TE, Felix, AS, Kaunitz, AM, Shadyab, AH, Qi, L., Wassertheil-Smoller, S., & Rohan, TE (2019). Associations of a Healthy Lifestyle Index with the Risks of Endometrial and Ovarian Cancer among Women in the Women’s Health Initiative Study. American Journal of Epidemiology, 188(2), 261–273. https://doi.org/10.1093/aje/kwy249

Bhatla, N., & Jones., A. (2018). The World Ovarian Cancer Coalition Atlas. In World Ovarian Cancer Coalition 2018 (April Issue).

Busmar, B. (2010). Ovarian Cancer. In MF Aziz, Andrijono, & AB Saifuddin (Eds.), National Reference Book of Gynecological Oncology (First, pp. 468–527). Bina Pustaka Sarwono Prawirohardjo Foundation.

Canadian Cancer Society. (2019). Ovarian Cancer.

Cirillo, P. M., Wang, E. T., Cedars, M. I., Chen, L., & Cohn, B. A. (2017). Irregular Menses Predicts Ovarian Cancer: Prospective Evidence from The Child Health and Development Studies. International Journal of Cancer, 139(5), 139–148. https://doi.org/10.1002/ijc.30144

Cooper, D. B., & Mahdy, H. (2019). Oral Contraceptive Pills. StatPearls Publishing.

Eric R. Craig, M., Angelina I. Londono, P., Lyse A. Norian, P., & Rebecca C. Arend, M. (2016). Metabolic Risk Factors and Mechanism of Disease in Epithelial Ovarian Cancer: A review. PMC Journal, 143(3), 674–683. https://doi.org/10.1016/j.ygyno.2016.10.005.

Furuya, M. (2012). Ovarian cancer stroma: Pathophysiology and the role in cancer development. Cancers, 4(3), 701–724. https://doi.org/10.3390/cancers4030701

Gajjar, K., Ogden, G., Mujahid, M.I., & Razvi, K. (2012). Symptoms and Risk Factors of Ovarian Cancer: A Survey in Primary Care. ISRN Obstetrics and Gynecology, 2012, 1–6. https://doi.org/10.5402/2012/754197

Globocan. (2019). Prostate Globocan 2018.

Gong, T.-T., Wu, Q.-J., Vogtmann, E., Lin, B., & Wang, Y.-L. (2014). Age at menarche and risk of ovarian cancer: a meta-analysis of epidemiological studies. International Journal of Cancer, 132(36), 2894–2900. https://doi.org/10.1002/ijc.27952.Age

Iversen, L., Fielding, S., Lidegaard, Ø., Mørch, L.S., Skovlund, C.W., & Hannaford, P.C. (2018). Association between contemporary hormonal contraception and ovarian cancer in women of reproductive age in Denmark: Prospective, nationwide cohort study. BMJ (Online), 362, 1–9. https://doi.org/10.1136/bmj.k3609

Lee, H., Leem, S., Oh, B., & Park, T. (2019). Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride. Hindawi, 2019(Oxidative Medicine and Cellular Longevity), 1999–2006.

Lundberg, F.E., Iliadou, A.N., Rodriguez-Wallberg, K., Gemzell-Danielsson, K., & Johansson, ALV (2019). The risk of breast and gynecological cancer in women with a diagnosis of infertility: a nationwide population-based study. European Journal of Epidemiology, 34(5), 499–507. https://doi.org/10.1007/s10654-018-0474-9

Momenimovahed, Z., Tiznobaik, A., Taheri, S., & Salehiniya, H. (2019). Ovarian cancer in the world: Epidemiology and risk factors. International Journal of Women’s Health, 11, 287–299. https://doi.org/10.2147/IJWH.S197604

Montes, AF, Gomez, JG, Viejo, MN, Bermejo, MA, Urrutia, SA, & Mata, JG (2012). Epidemiology and etiology of Ovarian Cancer. In DS Farghaly (Ed.), Ovarian Cancer-Basic Science Perspective (pp. 1–16). InTech.

Nissa, PAE, Widjajanegara, H., & Purbaningsih, W. (2017). Hormonal Contraception as a Risk Factor for Breast Cancer at Al-Ihsan Regional Hospital, Bandung. Bandung Meeting on Global Medicine & Health (BaMGMH), 1(1), 112–119.

Ose, J., Poole, E.M., Schock, H., Lehtinen, M., Arslan, A.A., Zeleniuch-jacquotte, A., Visvanathan, K., Helzlsouer, K., & Buring, J.E. (2018). Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium. PMC Journal, 77(14), 3951–3960. https://doi.org/10.1158/0008-5472.CAN-16-3322.Androgens

Præstegaard, C., Kjaer, SK, Nielsen, TSS, Jensen, SM, Webb, PM, Nagle, CM, Høgdall, E., Risch, HA, Rossing, MA, Doherty, JA, Wicklund, KG, Goodman, MT, Modugno, F., Moysich, K., Ness, R.B., Edwards, R.P., Goode, E.L., Winham, SJ, Fridley, B.L., … Jensen, A. (2016). The association between socioeconomic status and tumor stage at diagnosis of ovarian cancer: A pooled analysis of 18 case-control studies. Cancer Epidemiology, 41, 71–79. https://doi.org/10.1016/J.CANEP.2016.01.012

Razi, S., Ghoncheh, M., Mohammadian-Hafshejani, A., Aziznejhad, H., Mohammadian, M., & Salehiniya, H. (2016). The incidence and mortality of ovarian cancer and their relationship with the Human Development Index in Asia. Ecancermedicalscience, 10, 1–11. https://doi.org/10.3332/ecancer.2016.628

Reid, B. M., Permuth, J. B., & Sellers, T. A. (2017). Epidemiology of ovarian cancer: a review. Cancer Biology and Medicine, 14(1), 9–32. https://doi.org/10.20892/j.issn.2095-3941.2016.0084

Simamora, RPA, Hanriko, R., & Sari, RDP (2018). The relationship between age, number of parities, and age of menarche on the histopathological grade of ovarian cancer at RSUD Dr. H. Abdul Moeloek Bandar Lampung in 2015-2016. Majority, 7(2), 7–13.

Su, D., Pasalich, M., Lee, A.H., & Binns, C.W. (2013). Ovarian cancer risk is reduced by prolonged lactation: A case-control study in southern China. American Journal of Clinical Nutrition, 97(2), 354–359. https://doi.org/10.3945/ajcn.112.044719

Sumanasekera, W.K. (2018). Epidemiology of Ovarian Cancer: Risk Factors and Prevention. Biomedical Journal of Scientific & Technical Research, 11(2), 8405–8417. https://doi.org/10.26717/bjstr.2018.11.002076

Widayati, P., Ariyanto, A., & Lestari, W. (2011). Production of the CA-125 Immunoradiometricassay (IRMA) Kit for Early Detection of Ovarian Cancer. Radioisotopes And Radiopharmaceuticals, 14, 33–42.

Yanti, M. (2018). Analysis of factors influencing the incidence of ovarian cancer at the Regional General Hospital, Dr. Zainoel Abidin Banda Aceh 2017. University of North Sumatra.

Zheng, G., Yu, H., Kanerva, A., Forsti, A., Sundquist, K., & Hemminki, K. (2018). Familial risks of ovarian cancer by age at diagnosis, proband type and histology. PLOS ONE, 13(10), 1–10. https://doi.org/10.1371/journal.pone.0205000


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DOI: https://doi.org/10.26714/jk.13.1.2024.47-58

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