Email this article 
Number of Glia Cells in the Cerebrum and Cerebellum of Newborn Rats After Administration of Mackerel Fish Oil During Pregnancy
(1) Universitas Airlangga, Indonesia
(2) Universitas Airlangga, Indonesia
(3) Universitas Airlangga, Indonesia
(*) Corresponding Author
Abstract
Omega 3 intake during pregnancy can support fetal brain growth and development. Omega 3 plays an important role in making neuron cell membranes and glia and protecting nerve cells. Mackerel is a source of omega 3 which is abundant and easily accessible to the people of Indonesia. The purpose of this study was to analyze the effect of mackerel oil intake on the number of glial cells (astrocytes, oligodendrocytes, and microglia) of the cerebrum and cerebellum of newborn rats. This research was a true experimental design with a post-test only control group. A total of 30 pregnant rats were randomized into 3 groups, namely the control group (K1), mackerel oil (K2), and omega 3 supplements (K3). Each group was given treatment on days 1-17 of pregnancy. On the 18th day, the termination was carried out. 3 newborn rats were taken from each parent and made preparations from brain tissue. Hematoxylin-Eosin test to assess the number of glial cells. The results showed the highest mean±SD number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum was the highest in the mackerel oil group (174,460±33,777; 21,080±6,937; 11,300±2,090), and (156,280 ±34,980; 22,260±4,302; 11,060±2,383). ANOVA test showed a significant difference in the number of glial cells in the cerebrum and cerebellum between groups with a p-value <0.05. The results of this study can be concluded that the administration of mackerel oil during pregnancy can increase the number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum of newborn rats.
Keywords
Full Text:
PDFReferences
Asifa, C., & Rodiani, R. (2021). Suplementasi Docosahexaenoic Acid (DHA) Sebagai Usaha Preventif Ibu Hamil Dengan Risiko Preeklampsia. Jurnal Kesehatan, 14(1). https://doi.org/10.24252/kesehatan.v14i1.15442
Basak, S., Vilasagaram, S., & Duttaroy, A. K. (2020). Maternal dietary deficiency of n-3 fatty acids affects metabolic and epigenetic phenotypes of the developing fetus. Prostaglandins, Leukotrienes and Essential Fatty Acids, 158, 102109.
Bernardi, J. R., Escobar, R. de S., Ferreira, C. F., & Silveira, P. P. (2012). Fetal and neonatal levels of omega-3: effects on neurodevelopment, nutrition, and growth. The Scientific World Journal, 2012.
Cohen Kadosh, K., Muhardi, L., Parikh, P., Basso, M., Jan Mohamed, H. J., Prawitasari, T., Samuel, F., Ma, G., & Geurts, J. M. W. (2021). Nutritional support of neurodevelopment and cognitive function in infants and young children—an update and novel insights. Nutrients, 13(1), 199.
Coti Bertrand, P., O’Kusky, J. R., & Innis, S. M. (2006). Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. The Journal of Nutrition, 136(6), 1570–1575.
Cusick, S. E., & Georgieff, M. K. (2016). The role of nutrition in brain development: the golden opportunity of the “first 1000 days.” The Journal of Pediatrics, 175, 16–21.
DiNicolantonio, J. J., & O’Keefe, J. H. (2020). The importance of marine omega-3s for brain development and the prevention and treatment of behavior, mood, and other brain disorders. Nutrients, 12(8), 2333.
Fauzi, A., & Joewono, H. T. (2018). Fifty Percent Of Food Restriction During Gestation Reduced The Dendritic Density Of Cerebrum And Cerebellum Of Rattus Norvegicus’ Newborn. Majala Obstetri Dan Ginekologi, 26(3), 112–117.
Hadders-Algra, M. (2010). Effect of long-chain polyunsaturated fatty acid supplementation on neurodevelopmental outcome in full-term infants. Nutrients, 2(8), 790–804.
Indaryanto, F. R., Wardiatno, Y., & Tiuria, R. (2014). Struktur komunitas cacing parasitik pada ikan kembung (Rastrelliger spp.) di Perairan Teluk Banten dan Pelabuhan Ratu. Jurnal Ilmu Pertanian Indonesia, 19(1), 1–8.
Kemenkes. (2018). Hasil Utama Riskesdas Tahun 2018. https://www.depkes.go.id
Li, M., Francis, E., Hinkle, S. N., Ajjarapu, A. S., & Zhang, C. (2019). Preconception and prenatal nutrition and neurodevelopmental disorders: a systematic review and meta-analysis. Nutrients, 11(7), 1628.
Medina, J. M., & Tabernero, A. (2002). Astrocyte-synthesized oleic acid behaves as a neurotrophic factor for neurons. Journal of Physiology-Paris, 96(3–4), 265–271.
Muhamad, N. A., & Mohamad, J. (2012). Fatty acids composition of selected Malaysian fishes. Sains Malaysiana, 41(1), 81–94.
Sarih, K. (2020). Pengaruh Pemberian Daun Kelor (Moringa Oleifera) Pada Ibu Hamil Dan Menyusui Terhadap Kualitas Asi Dan Perkembangan Anak Usia 18–24 Bulan Di Kabupaten Jeneponto. Universitas Hasanuddin.
Setyo Mahanani Nugroho, Maratusholikhah Nurtyas, & Leni Rahmania Astuti. (2022). Pendampingan dan Pemberian Makanan Tambahan “Nugget Ikan Kembung” pada Ibu Hamil Anemia di Wilayah Kerja Puskesmas Depok 2, Sleman, Yogyakarta. Prosiding Seminar Nasional Pengabdian Masyarakat.
Simarmata, N., Sembiring, T., Faranita, T., & Pratita, W. (2012). Peranan asam lemak esensial terhadap perkembangan otak dan ketajaman penglihatan. Majalah Kedokteran Nusantara The Journal Of Medical School, 45(3).
Yunanto, A., & Dwi Sanyoto, D. (2016). Kapita Selekta Memori dan Nutrisi.
Zhang, Z., Fulgoni III, V. L., Kris-Etherton, P. M., & Mitmesser, S. H. (2018). Dietary intakes of EPA and DHA omega-3 fatty acids among US childbearing-age and pregnant women: an analysis of NHANES 2001–2014. Nutrients, 10(4), 416.
Article Metrics
Abstract view : 194 timesPDF - 3 times
DOI: https://doi.org/10.26714/jk.13.1.2024.35-40
Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Jurnal Kebidanan
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
JURNAL KEBIDANAN
Program Studi Kebidanan
Fakultas Ilmu Keperawatan dan Kesehatan
Universitas Muhammadiyah Semarang, Indonesia
NRC Building, 2nd FLoor
Jl. Kedungmundu Raya No. 18, Semarang
Tlp. +6224-76740288, Fax. +6224-76740287