Control Of Lipid Profile On Diabetes Mellitus Animal Models With Watercress And Black Rice Bran

Abstract

Abstract. Fluctuations of blood glucose levels in people with diabetes is a major cause of developing complications from
hyperglycemia ability to form the free radicals. Hyperglycemia condition that causes glucose autooxidation, protein
glycation, and polyol pathway activation so as to accelerate the formation of reactive oxygen compounds, further
increasing the modification of proteins, lipids, and DNA in various tissues. Various studies have been done, but they
rarely take advantage of local foodstuffs as a functional food therapy. Raw foods contain a powerful antioxidant that is a
combination of watercress and black rice bran. This study aimed to analyze the effect of functional food supplements to
changes in the lipid profile of experimental animals . The results showed that levels of total cholesterol and triglyceride
levels decreased significantly after being given the supplement. There is a significant increase in HDL levels in
experimental animals after supplementation for 4 weeks, however, supplementation is not significant effect on LDL
levels decrease.