Faktor Risiko Timbulnya Kelainan Kongenital

Mitayani Purwoko(1*)


(1) FK UMPalembang, Palembang
(*) Corresponding Author

Abstract


Usia harapan hidup seseorang dapat bervariasi tergantung di mana orang tersebut dibesarkan. Kesenjangan dalam bidang kesehatan terutama dirasakan pada penderita kelainan kongenital. Kelainan kongenital adalah suatu kondisi ketidaknormalan struktur atau fungsi tubuh yang muncul saat lahir. Apabila bayi terlahir dengan baik maka dapat menyebabkan disabilitas seumur hidup dan menyebabkan pengaruh negatif  bagi keluarga dan lingkungan. Beberapa faktor risiko yang memiliki peranan penting dalam timbulnya kelainan kongenital adalah nutrisi, usia orang tua, dan lingkungan. Konsumsi nutrisi yang tidak adekuat, konsumsi obat-obatan selama kehamilan, usia ibu dan ayah saat terjadi pembuahan, serta adanya paparan debu dan asap rokok pada lingkungan dapat menyebabkan kelainan kongenital.


Keywords


faktor risiko; kelainan kongenital; cacat bawaan; kelainan janin

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References


Marmot M, Friel S, Bell R, Houweling TA, Taylor S. Closing the gap in a generation: health equity through action on the social determinants of health. Lancet. 2008;372(9650):1661–9.

World Health Organization. Birth Defects. 2010.

Chen M-J, Karaviti LP, Roth DR, Schlomer BJ. Birth prevalence of hypospadias and hypospadias risk factors in newborn males in the United States from 1997 to 2012. J Pediatr Urol. 2018;1–7.

Badan Penelitian dan Pengembangan Kesehatan. Riset Kesehatan Dasar: Riskesdas 2013. Jakarta: BKementerian Kesehatan Republik Indonesia. Jakarta; 2013.

Kementerian Kesehatan RI. Kelainan Bawaan. Infodatin. 2018;

Maritska Z, Kinanti SRA. Kejadian dan Distribusi Kelainan Kongenital Pada Bayi Baru Lahir di RS dr . Moehammad Hoesin Palembang Periode Januari-November 2015. J Kedokt Unila. 2016;1(Oktober 2016):347–50.

Mustofa S, Susmiarsih T, Wikaningrum R. Prevalensi bayi lahir cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI. J Kedokt Yars. 2009;17(2):101–10.

Altunhan H, Annagür A, Konak M, Ertugrul S, Örs R, Koç H. The incidence of congenital anomalies associated with cleft palate/cleft lip and palate in neonates in the Konya region, Turkey. Br J Oral Maxillofac Surg. 2012;50(6):541–4.

Freitas JA de S, Neves LT das, Almeida ALPF de, Garib DG, Trindade-Suedam IK, Yaedú RYF, et al. Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies/USP (HRAC/USP) -Part 1: overall aspects. J Appl Oral Sci. 2012;20(1):9–15.

Gool JD Van, Hirche H, Lax H, Schaepdrijver L De. Folic acid and primary prevention of neural tube defects: A review. Reprod Toxicol. 2018;80(March):73–84.

Schoner K, Axt-Fliedner R, Bald R, Fritz B, Kohlhase J, Kohl T, et al. Fetal Pathology of Neural Tube Defects –An Overview of 68 Cases. Geburtshilfe Frauenheilkd. 2017;77(05):495–507.

Zhu Z, Cheng Y, Yang W, Li D, Yang X, Liu D, et al. Who Should Be Targeted for the Prevention of Birth Defects? A Latent Class Analysis Based on a Large, Population-Based, Cross-Sectional Study in Shaanxi Province, Western China. PLoS One. 2016;11(5):1–16.

Hynes KL, Otahal P, Burgess JR, Oddy WH, Hay I. Reduced educational outcomes persist into adolescence following mild iodine deficiency in Utero, despite adequacy in childhood: 15-Year Follow-Up of the gestational iodine cohort investigating auditory processing speed and working memory. Nutrients. 2017;9(12):1–19.

Haraux E,Tourneux P, Kouakam C, Stephan-Blanchard E, Boudailliez B, Leke A, et al. Isolated hypospadias: The impact of prenatal exposure to pesticides, as determined by meconium analysis. Environ Int. 2018;119(June):20–5.

Zambelli-weiner A, Via C, Yuen M, Weiner DJ, Kirby RS. First trimester ondansetron exposure and risk of structural birth defects. Reprod Toxicol. 2019;83(March 2018):14–20.

Danielsson B, Norstedt B, Källén B. Use of ondansetron during pregnancy and congenital malformations in the infant. Reprod Toxicol. 2014;50:134–7.

Fejzo MS, Macgibbon KW, Mullin PM. Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States. Reprod Toxicol. 2016;62:87–91.

Ms MMH, Carter TC, Browne ML, Romitti PA, Cunniff CM, Druschel CM, et al. Fluconazole use and birth defects in the National Birth Defects Prevention Study. Am J Obstet Gynecol. 2016;214(5):657.e1-657.e9.

Berg E, Lie RT, Sivertsen Å, Haaland ØA. Annals of Epidemiology Parental age and the risk of isolated cleft lip: a registry-based study. Ann Epidemiol. 2015;25(12):942–947.e1.

Green RF, Devine O, Crider KS, Olney RS, Archer N, Olshan AF, et al. Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study , 1997 to 2004. Ann Epidemiol. 2010;20(3):241–9.

Hurley EG, Defranco EA. Influence of paternal age on perinatal outcomes. Am J Obstet Gynecol. 2017;217(5):566.e1-566.e6.

Martelli DRB, Coletta RD, Oliveira EA, Swerts MSO, Rodrigues LAM, Oliveira MC, et al. Association between maternal smoking, gender, and cleft lip and palate. Braz J Otorhinolaryngol. 2015;81(5):514–9.

Liu X, Nie Z, Chen J, Guo X, Ou Y, Chen G, et al. Does maternal environmental tobacco smoke interact with social-demographics and environmental factors on congenital heart defects? *. Environ Pollut. 2018;234:214–22.

Ren S, Haynes E, Hall E, Hossain M, Chen A, Muglia L, et al. Periconception Exposure toAir Pollution and Risk of Congenital Malformations. J Pediatr. 2017;193:76–84.e6.

Salavati N, Strak M, Burgerhof JGM, de Walle HEK, Erwich JJHM, Bakker MK. The association of air pollution with congenital anomalies: An exploratory study in the northern Netherlands. Int J Hyg Environ Health. 2018;221(7):1061–7.

Lin TW, Wang JT. Prenatal Diagnosis of Hypospadias –A Case Report. J Med Ultrasound. 2017;25(2):115–7.


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DOI: https://doi.org/10.26714/magnamed.6.1.2019.51-56

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