Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

Andre Bagaskara(1*), Nenny Triastuti(2), Nurma Yuliyanasari(3), Yudith Annisa Ayu Rezkitha(4), Muhammad Anas(5), Ricky Indra Alfaray(6)


(1) Faculty of Medicine, Muhammadiyah University of Surabaya
(2) Faculty of Medicine, Muhammadiyah University of Surabaya
(3) Faculty of Medicine, Muhammadiyah University of Surabaya
(4) Faculty of Medicine, Muhammadiyah University of Surabaya
(5) Faculty of Medicine, Muhammadiyah University of Surabaya
(6) Faculty of Medicine Oita University,  Yufu City, Prefecture Oita
(*) Corresponding Author

Abstract


Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia.

Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen.

Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests.

Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000).

Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.


Keywords


putri; malu; hepatoprotector; Ibuprofen; SGOT; SGPT; hepatotoxic

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