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Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)
(1) Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
(2) Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
(3) Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
(4) Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
(5) Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya, East Java, Indonesia
(6) Faculty of Medicine Oita University, Yufu City, Prefecture Oita, Japan
(*) Corresponding Author
Abstract
Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia.
Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen.
Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests.
Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000).
Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.
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Parnanto NHR, Utami R, Sutanto A. Pengaruh Kemampuan Antioksidan dan Antibakteri pada Ekstrak Daun Putri Malu (Mimosa pudica) terhadap Kualitas Fillet Ikan Tongkol (Euthynnus affinis). J Teknosains Pangan. 2013;1(1):41–8.
Hrp MSB. THE LEVEL OF SGOT AND SGPT AFTER CONSUMING PUTRI MALU (Mimosa pudica, Linn) LEAVES BOILED ON CARBON TETRACHLORIDE (CCl4) …. FKIK (Pendidikan Dokter). 2012;9(2 (s)):81–5.
Syarif A. Farmakologi dan Terapi. Jakarta: FKUI; 2016.
Wójta-Kempa M, Krzyzanowski DM. Correlates of abusing and misusing over-the-counter pain relievers among adult population of Wrocław (Poland). Adv Clin Exp Med. 2016;25(2):349–60.
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. Sci World J. 2013;2013.
Rohmani A, Rakhmawatie MD. Efek Ekstrak Kulit Manggis Terhadap Gambaran Histopatologi Hepar Tikus Wistar Yang Diinduksi Formalin. MAGNA MEDICA Berk Ilm Kedokt dan Kesehat. 2016;1(2):88.
Hendra S. Praktikum Farmakologi. Jakarta Selatan: BPOM; 2016. 1–160 p.
Quatrone et al. Neurobiologi efek plasebo pada penyakit Parkinson: Apa yang telah kita pelajari dan ke mana kita pergi. Gangguan Gerak. 2018;12(2):91–6.
Khristivanie Y. Pemberian ekstrak etanol umbi bit merah (Beta Vulgaris) Oral dapat Menurunkan Kadar F2-Isoprostan pada Urin Tikus (Ratus Norvegicus) Wistar Jantan yang Diinduksi Aktivitas Fisik Berlebih. Universitas Udayana; 2017.
Arfeliana C. Pengaruh Pemberian Teh Hitam terhadap Kadar SGOT dan SGPT mencit BALB/C. FK Undip. Faculty of Medicine; 2010. p. 1–18.
Abbas MT, Abed RM, Metab NJ. The effect of olive oil ( Olea europaea ) on ibuprofen induced hepatotoxicity in female rats Mohammed Talat Abbass ( Karbala university / College of Pharmacy Department of Laboratory Sciences ), Rabab Murtadha Abed ( Karbala university / Pure Faculty of E. Kerbala J Pharm Sci. 2017;2017(13):178–87.
Gunawan SG. Farmakologi dan Terapi. 5ed ed. Jakarta: FKUI; 2012.
Rosida A. Pemeriksaan Laboratorium Penyakit Hati. Berk Kedokt. 2016;12(1):123.
K. J, G. N, C. K. Mimosa Pudica Linn- A shyness princess: A review of its plant movement, active constituents, uses and pharmacological activity. Int J Pharm Sci Res [Internet]. 2014;5(12):5104–18. Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L600641301%255Cnhttp://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5104-18%255Cnhttp://vb3lk7eb4t.search.serialssolutions.com?sid=EMBASE&issn=09758232&id=doi:10.13040%252FIJPSR.0975-82
Arianti N. Efek hepatoprotektor ekstrak herba putri malu (Mimosa Pudica L) terhadap Kadar Aminotransferase dan Alkalifosfatase Tikus Putih Jantan (Rattus Novergicus). Uiversitas Sebelas Maret; 2014. p. 1–86.
Rahmatia AR, Rinidar R, TR TA, Rosmaidar R, Harris A, Fahrimal Y. 15. Potency of Methanolic Extract of Sernai Stems (Wedelia biflora) as Analgesic on Mice (Mus musculus). J Med Vet. 2018;12(2):91–6.
Carter WC, Brown BR. Ibuprofen: Clinical pharmacology, medical uses and adverse effects. Ibuprofen: Clinical Pharmacology, Medical Uses and Adverse Effects. Nova Science Publishers, Incorporated; 2013. 1–404 p.
Zulizar AA. Pengaruh Parasetamol Dosis Analgetik Terhadap Kadar Serum Glutamat Oksaloasetat Transaminase Tikus Wistar Jantan. UNDIP; 2013.
Karlida I, Musfiroh I. Suhu Penyimpanan Bahan Baku Dan Produk Farmasi Di Gudang Industri Farmasi. Vol. 15, Farmaka. Farmaka; 2017. p. 58–67.
Direktorat Bina Farmasi Komunitas dan Klinik. Pedoman Penggunaan Obat Bebas dan Bebas Terbatas Departemen Kesehatan Republik Indonesia. Jakarta: Departemen Kesehatan RI; 2006. 10–79 p.
Kumaresan R. Chemistry and Biological Activities of Flavonoid. India: Departement of Biochemistry University of Allahabad; 2015.
Kusuma M, Susilorini T, Surjowardojo P. Pengaruh Lama Dan Suhu Penyimpanan Ekstrak Daun Sirih Hijau (Piper Betle Linn) Dengan Aquades Terhadap Daya Hambat Bakteri Streptococcus Agalactiae Penyebab Mastitis Pada Sapi Perah. TERNAK Trop J Trop Anim Prod. 2017;18(2):14–21.
Seja Y, Ardana M, Aryati F. Pengaruh Suhu dan Lama Penyimpanan Ekstrak Bawang Dayak (Eleutherine americana L (Merr)) terhadap Aktivitas Antibakteri. In: Proceeding of Mulawarman Pharmaceuticals Conferences. 2018. p. 150–5.
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DOI: https://doi.org/10.26714/magnamed.9.1.2022.01-09
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