The Effectiveness of Lactobacillus plantarum Administration in Patients with Atopic Dermatitis

Ismatu Aghni Fatwa Izzati(1*), Ratih Pramuningtyas(2), Rochmadina Suci Bestari(3), Nurhayani Nurhayani(4)


(1) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(2) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(3) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(4) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(*) Corresponding Author

Abstract


Background: Atopic dermatitis is a chronic and residual inflammatory skin disease with increased prevalence in every year. The medications that are often given can cause serious side effects if it given in the long-term. The treatment of Lactobacillus plantarum is expected to be safer long-term treatment option for patient with atopic dermatitis.

Objective: The objective is to determine the effectiveness treatment of Lactobacillus plantarum in patients with atopic dermatitis.

Method: The research design was a Systematic Review with a qualitative approach using meta-synthesis analysis type. The search was conducted on 3 databases: PubMed, Science Direct, and Google Scholar. 

Result: Total articles obtained were 239 with 16 duplicate data. 211 articles were included in the exclusion criteria and 5 articles were interventions with combination probiotics. So there are 7 articles included in the research with clinical trials, open trials, pilot studies, and 4 research using the randomized controlled trial Double Blind design. All results showed improvement in symptoms with the SCORAD index or Skindex-16. Several studies also measured IgE, IL-4, IL-10, IL-13, IL-17, the percentage of Th1, Th2, Treg, TGF-β, IFN-γ and obtained different  results. 

Conclusion: Treatment of Lactobacillus plantarum in patients with atopic dermatitis is effective to reducing symptoms and as an immunomodulator.

Keywords


Atopic dermatitis; probiotic; Lactobacillus plantarum

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DOI: https://doi.org/10.26714/magnamed.9.1.2022.43-50

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