The Effectiveness of Lactobacillus plantarum Administration in Patients with Atopic Dermatitis

Ismatu Aghni Fatwa Izzati(1*), Ratih Pramuningtyas(2), Rochmadina Suci Bestari(3), Nurhayani Nurhayani(4)


(1) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(2) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(3) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(4) Universitas Muhammadiyah Surakarta, Central Java, Indonesia
(*) Corresponding Author

Abstract


Background: Atopic dermatitis is a chronic and residual inflammatory skin disease with increased prevalence in every year. The medications that are often given can cause serious side effects if it given in the long-term. The treatment of Lactobacillus plantarum is expected to be safer long-term treatment option for patient with atopic dermatitis.

Objective: The objective is to determine the effectiveness treatment of Lactobacillus plantarum in patients with atopic dermatitis.

Method: The research design was a Systematic Review with a qualitative approach using meta-synthesis analysis type. The search was conducted on 3 databases: PubMed, Science Direct, and Google Scholar. 

Result: Total articles obtained were 239 with 16 duplicate data. 211 articles were included in the exclusion criteria and 5 articles were interventions with combination probiotics. So there are 7 articles included in the research with clinical trials, open trials, pilot studies, and 4 research using the randomized controlled trial Double Blind design. All results showed improvement in symptoms with the SCORAD index or Skindex-16. Several studies also measured IgE, IL-4, IL-10, IL-13, IL-17, the percentage of Th1, Th2, Treg, TGF-β, IFN-γ and obtained different  results. 

Conclusion: Treatment of Lactobacillus plantarum in patients with atopic dermatitis is effective to reducing symptoms and as an immunomodulator.

Keywords


Atopic dermatitis; probiotic; Lactobacillus plantarum

Full Text:

PDF

References


Djuanda A. Ilmu Penyakit Kulit dan Kelamin, Edisi 7. 2017.

Keles FF, Pandaleke HEJ, Mawu FO. Profil dermatitis atopik pada anak di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2013 – Desember 2015. e-CliniC. 2016;4(2).

Widaty S, Soebono H, Nilasari H, Listiawan Y, Siswati AS. Panduan Praktik Klinis Bagi Dokter Spesialis Kulit dan Kelamin di Indonesia. Vol. 74, Journal of Organic Chemistry. Jakarta: PERDOSKI; 2017. 1–420 p.

Wong ITY, Tsuyuki RT, Cresswell-Melville A, Doiron P, Drucker AM. Guidelines for the management of atopic dermatitis (eczema) for pharmacists. Can Pharm J. 2017;150(5):285–97.

Febrina D, Hindritiani R, Ruchiatan K. Laporan Kasus : Efek Samping Kortikosteroid Topikal Jangka Lama pada Wajah Pendahuluan Laporan Kasus. Syifa’ Med. 2018;8(2):68–76.

Holt J, Krieg N., Sneath PH., Al E. Bergey’s Manual of Determinative Bacteriology. 2000.

Kusuma KB. Probiotik dan Peranannya pada Penyakit Alergi Anak. 2017;44(6):441–4.

Mizock BA. Probiotics. Disease-a-Month. 2015;61(7):259–90.

Fuchs-Tarlovsky V, Marquez-Barba MF, Sriram K. Probiotics in dermatologic practice. Nutrition [Internet]. 2016;32(3):289–95. Available from: http://dx.doi.org/10.1016/j.nut.2015.09.001

Huang R, Ning H, Shen M, Li J, Zhang J, Chen X. Probiotics for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Cell Infect Microbiol. 2017;7:392.

Karim A, et al. Efek Pemberian Lactobacillus plantarum IS-10506 terhadap Indeks Scoring Atopic Dermatitis (SCORAD) Pasien Dermatitis Atopik Dewasa Derajat Ringan. Periodical of Dermatology and Venereology. 2019;31(3):85-92.

Bonita L, et al. Efektivitas Lactobacillus plantarum terhadap Serum Imunoglobulin E Total dan Indeks Scoring Atopic Dermatitis (SCORAD) Pasien Dermatitis Atopik Dewasa. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2019;31(3):78-84.

Prakoeswa CRS, Herwanto N, Prameswari R, Astari L, Sawitri S, Hidayati AN, et al. Lactobacillus plantarum IS-10506 supplementation reduced SCORAD in children with atopic dermatitis. Benef Microbes. 2017 Oct;8(5):833–40.

Han Y, Kim B, Ban J, Lee J, Kim BJ, Choi BS, et al. A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis. Pediatr allergy Immunol Off Publ Eur Soc Pediatr Allergy Immunol. 2012 Nov;23(7):667–73.

Kim J, Lee BS, Kim B, Na I, Lee J, Lee JY, et al. Identification of atopic dermatitis phenotypes with good responses to probiotics (Lactobacillus plantarum CJLP133) in children. Benef Microbes. 2017 Oct;8(5):755–61.

Harima-Mizusawa N, Kamachi K, Kano M, Nozaki D, Uetake T, Yokomizo Y, et al. Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials. Biosci microbiota, food Heal. 2016;35(1):29–39.

Fang Z, Lu W, Zhao J, Zhang H, Qian L, Wang Q, et al. Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study. Eur J Nutr. 2020 Aug;59(5):2119–30.

Rusu E et al. Prebiotics and probiotics in atopic dermatitis (Review). Exp Ther Med. 2019;926–931.

Song S, Bae DW, Lim K, Griffiths MW, Oh S. Cold stress improves the ability of Lactobacillus plantarum L67 to survive freezing. Int J Food Microbiol. 2014;191:135–43.

Park M-S, Song N-E, Baik S-H, Pae H-O, Park SH. Oral administration of lactobacilli isolated from Jeotgal, a salted fermented seafood, inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice. Exp Ther Med. 2017 Jul;14(1):635–41.


Article Metrics

Abstract view : 583 times
PDF - 145 times

DOI: https://doi.org/10.26714/magnamed.9.1.2022.43-50

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Indexed by

 

      

 

Creative Commons License

MAGNA MEDIKA by APKKM is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.