Potential Ekstract Of Red Betel Leaf (Piper crocatum Ruiz & Pav.) as a Natural Hand Sanitizer

Maya Monica Manurung(1), Tyas Hanurita Subekti(2), Nanda Dhea Ayu Sawitri(3), Iin Novita Nurhidayati Mahmuda(4*)


(1) Muhammadiyah University of Surakarta, Central Java, Indonesia
(2) Muhammadiyah University of Surakarta, Central Java, Indonesia
(3) Muhammadiyah University of Surakarta, Central Java, Indonesia
(4) Muhammadiyah University of Surakarta, Central Java, Indonesia
(*) Corresponding Author

Abstract


Background: Hands are the most common medium for spreading disease. Red betel leaf has antibacterial bioactive compounds such as flavonoids, alkaloids, polyphenols, tannins, and essential oils. The most common way to clean hands is to use hand sanitizer.

Objective: To determine the antibacterial potential of red betel leaf extract (Piper crocatum Ruiz & Pav.) against the growth of Staphylococcus aureus, Streptococcus pyogenes, and Salmonella typhi as an active ingredient in hand sanitizers. 

Methods: Each bacterium, namely Staphylococus aureus, Streptococcus pyogenes and Salmonella typhi were divided into 6 groups, PEG 5% as a negative control, clindamycin for Staphylococus aureus and Streptococcus pyogenes and chloramphenicol for Salmonella typhi as a positive control, 70% alcohol as a comparison for hand sanitizer, extract 20%, 40%, and 80% as treatment groups. The obstacle zone is measured using a ruler.

Results: Zones of inhibition against Staphylococus aureus, Streptococcus pyogenes, and Salmonella typhi were formed at concentrations of 20%, 40%, and 80%. Kruskal Wallis statistical analysis showed significant results with p=0.000.

Conclusion: Red betel leaf extract has statistically significant antibacterial activity against Staphylococcus aureus, Streptococcus pyogenes and Salmonella typhi. The extract concentration of 40% is the optimal concentration as a raw material for hand sanitizer.


Keywords


Red Betel Extract; Staphylococus aureus; Streptococcus pyogenes; Salmonella typhi; natural hand sanitizer

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References


Arisanty A, Abdullah T, Sukmawaty M. Formulasi dan Efek Anti Bakteri Sediaan Gel Pencuci Tangan dari Minyak Atsiri Daun Kemangi (Occimum basilicum L.) Terhadap Eschericia coli. Media Farm. 2019;15(2):163–70.

Vishwanath R, Selvabai AP, Shanmugam P. Detection of bacterial pathogens in the hands of rural school children across different age groups and emphasizing the importance of hand wash. J Prev Med Hyg. 2019;60(2):E103.

Risan MH. Isolation and Identification of Bacteria from under Fingernails. Intl J Curr Microbiol Appl Sci. 2017;6(8):3584–90.

Apriani L, Rahmawati R, Kurniatuhadi R. Deteksi Bakteri Salmonella Dan Shigella Pada Makanan Burger Di Sungai Raya Dalam Pontianak. Protobiont. 2019;8(3).

Karolina ME, Kusdiyah E, Aurora WID. Perbandingan Efektifitas Antibakteri Mencuci Tangan dengan Electrolyzed Oxidized Water (EOW) dan Dengan Sabun Antiseptik. Electron J Sci Environ Heal Dis. 2020;1(1).

Wasiaturrahmah Y, Jannah R. Formulasi dan Uji Sifat Fisik Gel Hand Sanitizer dari Ekstrak Daun Salam (Syzygium polyanthum). Borneo J Pharmascientech. 2018;2(2).

Asngad A, Subiakto DW. Potensi Ekstrak Biji Alpukat sebagai Hand Sanitizer Alami: Literatur Review. Bioeksperimen J Penelit Biol. 2020;6(2):106–15.

Olaniyan LWB, Mkwetshana N, Okoh AI. Triclosan in Water, Implications for Human and Environmental Health. Springerplus. 2016;5(1):1–17.

Alawiyah AL, Karmila A, Hajar DS, Pebriani F, Putri NLFH. Pelatihan Pembuatan Hand Sanitizer Alami dari Daun Sirih dan Jeruk Nipis di Desa Salamnunggal. Educivilia J Pengabdi pada Masy. 2021;2(2):117–26.

Sitanggang IM. Analisis Dan Perbandingan Metode Sobel Dan Canny Pada Deteksi Tepi Citra Daun Sirh Merah. J Ilmu Komput dan Sist Inf. 2020;3(1.1):140–9.

Rachmawaty FJ, Akhmad MM, Pranacipta SH, Nabila Z, Muhammad A. Optimasi ekstrak etanol daun sirih merah (Piper crocatum) sebagai antibakteri terhadap bakteri Staphylococcus aureus. J Kedokt dan Kesehat. 2018;18(1):13–6.

Hurria H. Formulasi, Uji Stabilitas Fisik, dan Uji Aktifitas Sediaan Gel Hand Sanitizer dari Air Perasan Jeruk Nipis (Citrus aurantifolia SWINGLE) Berbasis Karbomer. J Farm UIN Alauddin Makassar. 2014;2(1):28–34.

Rahayu EDS. Efektivitas Daun Mimba (Azadirachta indica A. Juss) sebagai Desinfektan Alami terhadap Daya Hambat Bakteri Total di Ruang Penampungan Susu. Gontor AGROTECH Sci J. 2018;4(1):45–55.

Candrasari A, Romas MA, Astuti OR. Uji Daya Antimikroba Ekstrak Etanol Daun Sirih Merah (Piper Crocatum Ruiz & Pav.) Terhadap Pertumbuhan Staphylococcus aureus ATCC 6538, Eschericia Coli ATCC 11229 Dan Candida Albicans ATCC 10231 Secara In Vitro. Biomedika. 2012;4(1).

Afifi R, Erlin E, Rachmawati J. Uji Anti Bakteri Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L) terhadap Zona Hambat Bakteri Jerawat Propionibacterium acnes Secara In Vitro. Quagga J Pendidik dan Biol. 2018;10(01):10–7.

Rahman FA, Haniastuti T, Utami TW. Skrining Fitokimia dan Aktivitas Antibakteri Ekstrak Etanol Daun Sirsak (Annona muricata L.) pada Streptococcus mutans ATCC 35668. Maj Kedokt Gigi Indones. 2017;3(1):1–7.

Afiff FE, Amilah S. Efektivitas Ekstrak Daun Mengkudu (Morinda citrifolia L.) dan Daun Sirih Merah (Piper crocatum Ruiz & Pav) Terhadap Zona Hambat Pertumbuhan Staphylococcus aureus. STIGMA J Mat dan Ilmu Pengetah Alam Unipa. 2017;10(01).

Fadlilah M. Benefit of Red Betel (Piper crocatum Ruiz & Pav.) as Antibiotics. J Major. 2015;4(3).

Januarti IB, Wijayanti R, Wahyuningsih S, Nisa Z. Potensi Ekstrak Terpurifikasi Daun Sirih Merah (Piper crocatum Ruiz &Pav) sebagai Antioksidan dan Antibakteri. J Pharm Sci. 2019;2:61.

Wati YS, Zukhra RM, Permanasari I. Konsumsi Rebusan Daun Sirih Merah Efektif Terhadap Perubahan Kadar Gula Darah Penderita Diabetes Mellitus. Al-Insyirah Midwifery J Ilmu Kebidanan (Journal Midwifery Sci. 2020;9(2):91–9.


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DOI: https://doi.org/10.26714/magnamed.10.2.2023.141-149

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