Comparison of Pericanalicular and Intracanalicular Fibroadenoma Mammae Growth Pattern on Various Age Range

Hilda Maulyda Utamie(1*), Ira Citra Ningrom(2), Yuhantoro Budi Handoyo Sakti(3), Andi Muh. Maulana(4)

(1) Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
(2) Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
(3) Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
(4) Universitas Muhammadiyah Purwokerto, Central Java, Indonesia
(*) Corresponding Author


Background: Fibroadenoma mammae is the most common type of benign breast tumor in women. Fibroadenoma mammae can occur on various ages, there is no much data recorded about anatomical pathology especially regarding the distribution of fibroadenoma mammae growth pattern in Siaga Medika Purbalingga Hospital. Study in Indonesia that focus on this topic also remain scarce.

Objective: To analyze comparison between the growth pattern in fibroadenoma mammae patients with age range 11-50 years.

Method: This cross-sectional study with data collected restrospectively based on medical records and histopatological examination in Siaga Medika Purbalingga Hospital. Statistical analysis was done using JASP

Results: The majority of patients with fibroadenoma mammae were in the age range 21-30 years (48.9%) with pericanalicular pattern (66%). The four groups had different two growth pattern (p <0.001). Odds ratio showed 3.4 that means patient with age ≤30 years has chance 3.4x to diagnose with pericanalicular fibroadenoma mammae than patient with age >30 years.

Conclusion: Incidence of pericanalicular and intracanalicular fibroadenoma mammae growth pattern in Siaga Medika Purbalingga Hospital patients can be affected by age.


Fibroadenoma Mammae; Age; Pericanalicular; Intracanalicular

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Ahsani RF, Machmud PB. Hubungan Riwayat Reproduksi dengan Tumor Payudara pada Perempuan Usia Muda di Indonesia (Analisis Riset PTM 2016). Media Kesehat Masy Indones. 2019;15(3):237.

Samosir BP, Angka RN, Christina S, Endarjo S, Pandansari P, Anatomi DH, et al. Gambaran Pasien dengan Benjolan Payudara yang Diperiksa Biopsi Aspirasi Jarum Halus di Yayasan Kanker Indonesia Tahun 2014-2018 Description of Breast Lump Patients Performing Fine Needle Aspiration Biopsy at The Indonesia Cancer Foundation in 2014-2018. 2018;27(1):9–15.

Williams HJ. Educational Case: Fibroadenoma of the Breast. Acad Pathol. 2018;5:237428951879092.

Neville G, Neill CO, Murphy R, Corrigan M, Redmond PH, Feeley L, et al. Is excision biopsy of fibroadenomas based solely on size criteria warranted? Breast J. 2018;24(6):981–5.

Cardoso ABA, Schröder GC, Zimermann P, Almendra TSL, Pinto ASB. Complex fibroadenoma: bibliometric literature review and presentation of a clinical case. Mastology. 2020;30:1–7.

Begum R, Thomus R, Babu N. Chances of breast cancer with fibroadenoma-Review. J Sci Innov Res. 2017;6(2):84–6.

Johansson A, Christakou AE, Iftimi A, Eriksson M, Tapia J, Skoog L, et al. Characterization of Benign Breast Diseases and Association with Age, Hormonal Factors, and Family History of Breast Cancer among Women in Sweden. JAMA Netw Open. 2021;4(6):1–12.

Nassar A, Visscher DW, Degnim AC, Frank RD, Vierkant RA, Frost M, et al. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study. Breast Cancer Res Treat. 2015;153(2):397–405.

Sun C, Zhang W, Ma H, Han N, Qi M, Li D, et al. Main Traits of Breast Fibroadenoma among Adolescent Girls. Cancer Biother Radiopharm. 2020;35(4):271–6.

Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, et al. Genetics and genomics of breast fibroadenomas. J Clin Pathol. 2018;71(5):381–7.

Singh S, Khajuria M, Kaul R, Chauhan A, Panwar R. Histological changes associated with fibroadenoma breast. IP Arch Cytol Histopathol Res. 2020;3(3):136–9.

Baral S, Gyawali M, Thapa N, Chhetri RK, Dahal P. Giant juvenile fibroadenoma in an adolescent female: A case report. Clin Case Reports. 2020;8(12):3489–93.

Makkar N, Singh S, Paul S, Sandhu MS, Kumar A. Bilateral giant juvenile fibroadenoma of breast. J Clin Diagnostic Res. 2017;11(6):ED10–2.

Saeed M, Saif A Bin, Zafar H, Mushtaq A, Hashmi T, Tariq M. A S S O C I A T I O N O F M A R I T A L S T A T U S , E A R L Y M A R R I A G E A N D P A R I T Y W I T H. 2021;71(1):73–8.

Tummidi S, Kothari K, Agnihotri M, Naik L, Sood P. Fibroadenoma versus phyllodes tumor: A vexing problem revisited! BMC Cancer. 2020;20(1):1–12.

Piscuoglio S, Geyer FC, Burke KA, Murray MP, Ng CKY, Mota A, et al. Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor. npj Breast Cancer [Internet]. 2016;2(1):1–7. Available from:

AlGhamdi S, Ali AG, Ali SN, Rasheed K, Yousef Y. Giant juvenile fibroadenoma of breast in adolescent girls. J Pediatr Surg Case Reports. 2018;28(September 2017):33–6.

Saadaat R, Abdul-Ghafar J, Haidary AM, Rahmani S, Atta N. Age distribution and types of breast lesions among Afghan women diagnosed by fine needle aspiration cytology (FNAC) at a tertiary care centre in Afghanistan: A descriptive cross-sectional study. BMJ Open. 2020;10(9):1–6.

Stachs A, Stubert J, Reimer T, Hartmann S. Benign breast disease in women. Dtsch Arztebl Int. 2019;116(33–34):565–73.

Laxman S, Sangolgi P, Jabshetty S, Bhavikatti A, Uttam A. Clinical profile of patients with fibroadenoma of breast. Int Surg J. 2018;5(3):1057.

Erickson LA, Chen B. Fibroadenoma of the Breast. Mayo Clin Proc [Internet]. 2020;95(11):2573–4. Available from:

Huang IC, Li PC, Ding DC. Recurrent juvenile fibroadenoma of the breast in an adolescent: A case report. Med (United States). 2018;97(20):0–2.

Ansari JN, Buch AC, Pandey A, Rao R, Siddique A. Spectrum of histopathological changes in fibroadenoma of breast. Indian J Pathol Oncol. 2020;5(3):429–34.

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