Drosophila Melanogaster Utilization in Genetics Lectures: Innovations that Need to be Optimized

Diani Fatmawati(1), Maryam Saleem(2), Iin Hindun(3), Indah Permatasari(4), Solikhah Solikhah(5), Diana Khoiroh(6), Ahmad Fauzi(7*)


(1) Universitas Muhammadiyah Malang
(2) Government College University Faisalabad
(3) Universitas Muhammadiyah Malang
(4) Universitas Muhammadiyah Malang
(5) Universitas Muhammadiyah Malang
(6) Universitas Muhammadiyah Malang
(7) Universitas Muhammadiyah Malang
(*) Corresponding Author

Abstract


Drosophila melanogaster is a popular model organism that plays a role in the development of Genetics research and learning. The purpose of this study was to map Genetics lecture activities in Indonesia based on the utilization of Drosophila melanogaster during practicum activities. The data was collected using Google Form-based questionnaire analyzed using descriptive statistical analysis. A total of 113 alumni from 39 universities in Indonesia were involved as participants. The results informed that 77% of institutions had conducted Genetic Practicums and more than half had used Drosophila melanogaster. However, optimizing the use of these organisms in learning needs to be improved because the use of Drosophila melanogaster is still limited to morphological, chromosome, life cycle, and inheritance pattern observations.


Keywords


Drosophila melanogaster; Fruit flies; Genetics education; Model organism

Full Text:

PDF

References


Adedeji, A. A., & Vicente-Crespo, M. (2017). Rejuvenating research and training in biomedical sciences in Nigeria: Drosophila melanogaster as a versatile alternative model. Archives of Basic & Applied Medicine, 5, 1–10. http://archivesbamui.com/ojs/index.php/abam/article/download/3/1

Allendorf, F. W., Hohenlohe, P. A., & Luikart, G. (2010). Genomics and the future of conservation genetics. Nature Reviews Genetics, 11(10), 697–709. https://doi.org/10.1038/nrg2844

Allocca, M., Zola, S., & Bellosta, P. (2018). The fruit fly, Drosophila melanogaster: Modeling of human diseases (Part II). In Drosophila melanogaster - Model for Recent Advances in Genetics and Therapeutics. InTech. https://doi.org/10.5772/intechopen.73199

Banerjee, S., Benji, S., Liberow, S., & Steinhauer, J. (2020). Using Drosophila melanogaster to discover human disease genes: An educational primer for use with “amyotrophic lateral sclerosis modifiers in drosophila reveal the phospholipase d pathway as a potential therapeutic target.” Genetics, 216(3), 633–641. https://doi.org/10.1534/genetics.120.303495

Battista, R. N., Blancquaert, I., Laberge, A.-M., van Schendel, N., & Leduc, N. (2012). Genetics in health care: An overview of current and emerging models. Public Health Genomics, 15(1), 34–45. https://doi.org/10.1159/000328846

Byrne, M. (2018). A molecular journey in conservation genetics. Pacific Conservation Biology, 24(3), 235. https://doi.org/10.1071/PC18025

Camargo, F. de, & Miguel, G. (2019). The role of molecular genetics in livestock production. Animal Production Science, 59(2), 201–206. https://doi.org/10.1071/AN18013

Chyb, S., & Gompel, N. (2013). Atlas of drosophila morphology : wild-type and classical mutants. Academic Press.

Çimer, A. (2012). What makes biology learning difficult and effective: Students’ views. Educational Research and Reviews, 7(3), 61–71. https://doi.org/10.5897/ERR11.205

Delventhal, R., & Steinhauer, J. (2020). A course-based undergraduate research experience examining neurodegeneration in Drosophila melanogaster teaches students to think, communicate, and perform like scientists. PLoS ONE, 15(4), 1–22. https://doi.org/10.1371/journal.pone.0230912

Fauzi, A., & Corebima, A. D. (2016). Pemanfataan Drosophila melanogaster sebagai organisme model dalam mengungkap berbagai fenomena penyimpangan rasio Mendel. Seminar Nasional Biologi 2016, 278–282.

Fauzi, A., & Ramadani, S. D. (2017). Learning the genetics concepts through project activities using Drosophila melanogaster: A qualitative descriptive study. JPBI (Jurnal Pendidikan Biologi Indonesia), 3(3), 238–247. https://doi.org/10.22219/jpbi.v3i3.4540

Fauzi, A., Rosyida, A. M., Rohma, M., & Khoiroh, D. (2021). The difficulty index of biology topics in Indonesian Senior High School: Biology undergraduate students’ perspectives. JPBI (Jurnal Pendidikan Biologi Indonesia), 7(2), 149–158. https://doi.org/10.22219/jpbi.v7i2.16538

Fidiastuti, H. R., Lathifah, A. S., Amin, M., Utomo, Y., & Aldya, R. F. (2021). Improving student’s motivation and learning outcomes through genetics e-module. Jurnal Ilmiah Peuradeun, 9(1), 189–200. https://doi.org/10.26811/peuradeun.v9i1.477

Gittelman, M. (2016). The revolution re-visited: Clinical and genetics research paradigms and the productivity paradox in drug discovery. Research Policy, 45(8), 1570–1585. https://doi.org/10.1016/j.respol.2016.01.007

Grace, E. N. (2021). The problems of teaching and learning genetics in secondary schools in Enugu South Local Government Area of Enugu State. British International Journal of Education And Social Sciences, 8(4), 13–19. https://www.cirdjournal.com/index.php/bijess/article/download/230/224

Haambokoma, C. (2007). Nature and causes of learning difficulties in genetics at high school level in Zambia. Journal of International Development and Cooperation, 13(1), 1–9. https://doi.org/10.15027/28479

Hales, K. G., Korey, C. A., Larracuente, A. M., & Roberts, D. M. (2015). Genetics on the fly: A primer on the Drosophila model system. Genetics, 201(3), 815–842. https://doi.org/10.1534/genetics.115.183392

Heil, C. S. S., Manzano-Winkler, B., Hunter, M. J., Noor, J. K. F., & Noor, M. A. F. (2013). Witnessing evolution first hand: A K–12 laboratory exercise in genetics & evolution using Drosophila. The American Biology Teacher, 75(2), 116–119. https://doi.org/10.1525/abt.2013.75.2.8

Infante-malachias, M. E., Queiroz, I., Padilha, D. M., Artes, E. De, Humanidades, C., & Paulo, U. D. S. (2010). Comprehension of basic genetic concepts by brazilian undergraduate students. Revista Electrónica de Enseñanza de Las Ciencias, 9(3), 657–668.

Intra, J., & Pasini, M. E. (2016). The fruit fly Drosophila as a powerful tool in teaching life sciences in middle and high school classrooms. International Journal of Innovation and Research in Educational Sciences, 3(5), 288–295. https://www.ijires.org/administrator/components/com_jresearch/files/publications/IJIRES_688_FINAL.PDF

Lewin, B. (2008). Genes IX. Jones and Bartlett Publishers.

Lyu, S., & Tonoki, A. (2019). Drosophila behavior genetics. In Encyclopedia of Animal Behavior (pp. 259–266). Elsevier. https://doi.org/10.1016/B978-0-12-809633-8.20689-4

Mardin, H. (2017). Analisis kesulitan belajar biologi peserta didik kelas XII IPA SMA Negeri di Kota Palopo. Universitas Negeri Makassar.

Marshall, P. A. (2008). Development of higher-level cognitive skills in a learner-centered lab on extensions of Mendelian Inheritance using Drosophila. Journal of Microbiology & Biology Education, 9(1), 12–24. https://doi.org/10.1128/jmbe.v9.90

Morris, J. (2018). What genetic concept(s) do you think are the hardest for the students to grasp? Trends in Genetics, 34(3), 162–164. https://doi.org/10.1016/j.tig.2018.01.007

Nadeem, M. A., Nawaz, M. A., Shahid, M. Q., Doğan, Y., Comertpay, G., Yıldız, M., Hatipoğlu, R., Ahmad, F., Alsaleh, A., Labhane, N., Özkan, H., Chung, G., & Baloch, F. S. (2018). DNA molecular markers in plant breeding: current status and recent advancements in genomic selection and genome editing. Biotechnology & Biotechnological Equipment, 32(2), 261–285. https://doi.org/10.1080/13102818.2017.1400401

Pasini, M. E., Bertolotto, F., & Fasano, P. (2010). The role of models in science: an experience with Drosophila. Procedia - Social and Behavioral Sciences, 2(2), 1164–1168. https://doi.org/10.1016/j.sbspro.2010.03.166

Ramadani, S. D. (2018). Pengembangan modul genetika berbasis praktikum proyek memanfaatkan Drosophila melanogaster pada topik regulasi ekspresi gen eukariot. Wacana Didaktika, 6(2), 140–154. https://doi.org/10.31102/wacanadidaktika.6.02.140-154

Ramadhan, T., & Suyanto, S. (2020). Biology science practicum learning: An evaluation study in junior high school of Ngemplak-Indonesia. JPBI (Jurnal Pendidikan Biologi Indonesia), 6(3), 361–366. https://doi.org/10.22219/jpbi.v6i3.13657

Rothhaas, S., Wright, M. C., & Swanson, C. (2020). Using Drosophila motor mutants to teach neurodevelopment in an undergraduate neurobiology lab. Journal of Undergraduate Neuroscience Education, 18(2), A93–A101. http://www.ncbi.nlm.nih.gov/pubmed/32848517

Sharma, B. (2014). Drug resistance in HIV-1: Genetic and molecular bases, mechanisms and strategies to combat the issue. Biochemistry & Analytical Biochemistry, 4(1). https://doi.org/10.4172/2161-1009.1000e153

Slamet, A., Taharu, F. I., & Hudha, A. M. (2019). Developing genetic learning module based on blue eyes phenomenon in Buton Island, Southeast Sulawesi. Jurnal Pendidikan Biologi Indonesia, 5(1), 69–76. https://doi.org/10.22219/jpbi.v5i1.7071

Snustad, D. P., & Simmons, M. J. (2012). Genetics. Wiley.

Stephenson, R., & Metcalfe, N. (2013). Drosophila melanogaster: A fly through its history and current use. The Journal of the Royal College of Physicians of Edinburgh, 43(1), 70–75. https://doi.org/10.4997/JRCPE.2013.116

Tolwinski, N. (2017). Introduction: Drosophila—A model system for developmental biology. Journal of Developmental Biology, 5(3), 9. https://doi.org/10.3390/jdb5030009

Topçu, M. S., & Şahin-Pekmez, E. (2009). Turkish middle school students’ difficulties in learning genetics concepts. Journal of Turkish Science Education, 6(2), 55–62. http://www.tused.org/internet/tused/archive/v6/i2/text/tusedv6i2s5.pdf

Venema, D. R. (2006). Enhancing undergraduate teaching and research with a Drosophila virginizing system. CBE Life Sciences Education, 5(4), 353–360. https://doi.org/10.1187/cbe.06-03-0152

Wangler, M. F., Yamamoto, S., Chao, H.-T., Posey, J. E., Westerfield, M., Postlethwait, J., Members of the Undiagnosed Diseases Network (UDN), M. of the U. D. N., Hieter, P., Boycott, K. M., Campeau, P. M., & Bellen, H. J. (2017). Model organisms facilitate rare disease diagnosis and therapeutic research. Genetics, 207(1), 9–27. https://doi.org/10.1534/genetics.117.203067

Wolfram, J. A., & Donahue, J. K. (2013). Gene therapy to treat cardiovascular disease. Journal of the American Heart Association, 2(4), 1–11. https://doi.org/10.1161/JAHA.113.000119

Wong, K., & Xie, G. (2017). Updates on the molecular genetics of colorectal cancer. Colorectal Cancer: Open Access, 3(1), 1–8. https://doi.org/10.21767/2471-9943.100032

Yamaguchi, M., & Yoshida, H. (2018). Drosophila as a model organism. In Advances in Experimental Medicine and Biology (pp. 1–10). Springer. https://doi.org/10.1007/978-981-13-0529-0_1


Article Metrics

Abstract view : 882 times
PDF - 173 times

DOI: https://doi.org/10.26714/jps.10.1.2022.22-27

Refbacks

  • There are currently no refbacks.


Copyright (c) 2022 JURNAL PENDIDIKAN SAINS (JPS)

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

EXECUTIVE OFFICE

JURNAL PENDIDIKAN SAINS UNIVERSITAS MUHAMMADIYAH SEMARANG
DEPARTMENT OF CHEMISTRY EDUCATION
FACULTY OF MATHEMATICS AND NATURAL SCIENCES
MUHAMMADIYAH SEMARANG UNIVERSITY

Jl. Kedungmundu Raya No.18, Semarang, Jawa Tengah, Indonesia
    Telp. (024)76740231, 76740231
    email: jps@unimus.ac.id


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License

Journal Pendidikan Saisn (JPS)
ISSN:2339-0786, e-ISSN:2502-1443
Published by: Chemistry Education, Muhammadiyah Semarang University