Impact of Single vs Combination Anti-Hyperglycemic Drug Therapy on HbA1c Levels: A Cross-Sectional Study

Devita Diatri(1*), Maya Dian Rakhmawatie(2)


(1) Faculty of medicine, Universitas Muhammadiyah Semarang
(2) Faculty of medicine, Universitas Muhammadiyah Semarang
(*) Corresponding Author

Abstract


Diabetes Mellitus (DM) is a long-term medical condition characterized by increased blood glucose levels caused by abnormalities in the insulin metabolism process. Various types of antihyperglycemic drugs are available, both as single and combination therapy. Recent research shows that single or combination therapy can impact glycemic control differently, especially when looking at changes in HbA1C levels.  This research is descriptive-analytical with a cross-sectional design using medical record data from Type 2 DM patients in the 2022-2023 period.  Data was analyzed using SPSS. In this study, there was a significant relation between single and combination anti-hyperglycemic drug therapy. Bivariate analysis showed that both single and combination therapy were associated with a reduction in HbA1C levels, with a p-value of 0.019. There is a correlation between HbA1C levels and single and combination therapy in type 2 DM patients at the Prolanis Clinic.

Keywords


diabetes mellitus; HBA1C; therapy

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References


Sharma A, Mittal S, Aggarwal R, Chauhan MK. Diabetes and cardiovascular disease: inter-relation of risk factors and treatment. Future Journal of Pharmaceutical Sciences. 2020;6(1).

Sarwar N, Gao P, Kondapally Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio E, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. The Lancet. 2010;375(9733):2215–22.

Kyrou I, Tsigos C, Mavrogianni C, Cardon G, Van Stappen V, Latomme J, et al. Sociodemographic and lifestyle-related risk factors for identifying vulnerable groups for type 2 diabetes: A narrative review with emphasis on data from Europe. BMC Endocrine Disorders. 2020;20(Suppl 1):1–13.

Safitri AZ, Fajariyah RN, Astutik E. Risk Factors of Diabetes Mellitus in Urban Communities in Indonesia (IFLS 5). Jurnal Berkala Epidemiologi. 2021;9(2):184.

Westman EC. Type 2 Diabetes Mellitus: A Pathophysiologic Perspective. Frontiers in Nutrition. 2021;8(August):1–5.

Arifin B, van Asselt ADI, Setiawan D, Atthobari J, Postma MJ, Cao Q. Diabetes distress in Indonesian patients with type 2 diabetes: a comparison between primary and tertiary care. BMC health services research. 2019;19(1):773.

Cahn A, Cefalu WT. Clinical considerations for use of initial combination therapy in type 2 diabetes. Diabetes Care. 2016;39(August):S137–45.

Benoit SR, Hora I, Albright AL, Gregg EW. New directions in incidence and prevalence of diagnosed diabetes in the USA. BMJ Open Diabetes Research and Care. 2019;7(1):1–6.

Schlender L, Martinez Y V., Adeniji C, Reeves D, Faller B, Sommerauer C, et al. Efficacy and safety of metformin in the management of type 2 diabetes mellitus in older adults: A systematic review for the development of recommendations to reduce potentially inappropriate prescribing. BMC Geriatrics. 2017;17(Suppl 1).

Yusmaniar, Kurniawan AH, Surahman, Fauzan MN. Treatment Pattern and Cost-Effectiveness Analysis of Oral Hypoglycemics for Type 2 Diabetes Mellitus Outpatients At Regional General Hospital, Indonesia. Malaysian Journal of Public Health Medicine. 2022;22(2):27–34.

Omar MAK, Christopher L, Motala AA, Jialal I, Seedat MA. Management of diabetes mellitus. South African Medical Journal. 1987;71(9):580–4.

Xie X, Wu C, Hao Y, Wang T, Yang Y, Cai P, et al. Benefits and risks of drug combination therapy for diabetes mellitus and its complications: a comprehensive review. Frontiers in Endocrinology. 2023;14(December):1–17.

Evert AB, Dennison M, Gardner CD, Timothy Garvey W, Karen Lau KH, MacLeod J, et al. Nutrition therapy for adults with diabetes or prediabetes: A consensus report. Diabetes Care. 2019;42(5):731–54.

Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical activity/exercise and diabetes: A position statement of the American Diabetes Association. Diabetes Care. 2016;39(11):2065–79.

Suda N, Lee HJ. Initial Diagnosis and Management of Type 2 Diabetes Mellitus. A Case-Based Guide to Clinical Endocrinology, Third Edition. 2022;353–67.

Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, et al. Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy. Diabetes Care. 2024;47(4):571–9.


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DOI: https://doi.org/10.26714/seanr.6.2.2024.79-83

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