Impact of radiation therapy on the heart

Siti Utami Dewi(1*), Allenidekania Allenidekania(2)


(1) STIKes Fatmawati
(2) Fakultas Ilmu Keperawatan, Universitas Indonesia
(*) Corresponding Author

Abstract


Radiation therapy is the most important part of a modality in the management of patients with malignancy. The incidence of heart disease caused by radiation has increased in recent decades, due to the increased survival rate of patients with malignancies in the chest area receiving radiation therapy. Purpose To determine the impact on the heart due to radiation therapy in cancer patients. This study is a literature review, articles were collected using Google Scholar, ScienceDirect, and PubMed databases with the keywords radiation, heart disease, cancer patients, and radiotherapy. Inclusion criteria included articles published from 2013-2022. Based on a review of 10 articles discussing the effect of radiation therapy on the heart. Some cardiovascular complications due to radiation therapy can affect the pericardial, myocardial, vascular, heart valves, and conduction disturbances. Radiation-induced heart disease is a growing concern because it is associated with increased survival in cancer patients. It is important for clinicians to understand the impact of radiation therapy on the heart for the purposes of education, consideration of therapy and dose, monitoring of therapy, and early detection.

Keywords


Heart; Cancer; Radiation; Therapy

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References


Kemenkes. Riset Kesehatan Dasar. Jakarta: Kemenkes RI; 2013.

National Instituse of Health. Treatment for cancer-National Cancer.

Fitriatuzzakiyyah N, Sinuraya RK, Puspitasari IM. Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in Indonesia. Indones J Clin Pharm. 2017;6(4):311–20.

Cutter DJ, Darby SC, Yusuf SW. Risks of heart disease after radiotherapy. Texas Hear Inst J. 2011;38(3):257–8.

Beyzadeoglu M, Ozyigit G, Ebruli C. Basic Radiation Oncology. In Turkey: University of Health Sciences Turkey; 2018.

Yusuf SW, Sami S, Daher IN. Radiation-induced heart disease: A clinical update. Cardiol Res Pract. 2011;1(1).

Jaworski C, Mariani JA, Wheeler G, Kaye DM. Cardiac complications of thoracic irradiation. J Am Coll Cardiol. 2013;61(23):2319–28.

Lancellotti P, Nkomo VT, Badano LP, Bergler-Klein J, Bogaert J, Davin L, et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2013;14(8):721–40.

Groarke JD, Nguyen PL, Nohria A, Ferrari R, Cheng S, Moslehi J. Cardiovascular complications of radiation therapy for thoracic malignancies: The role for non-invasive imaging for detection of cardiovascular disease. Eur Heart J. 2014;35(10):612–23.

Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: Pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5(FEB):1–8.

Xu T, Meng QH, Gilchrist SC, Lin SH, Lin R, Xu T, et al. Assessment of Prognostic Value of High- Sensitivity Cardiac Troponin T for Early Prediction of Chemoradiation Therapy-Induced Cardiotoxicity in Patients with Non-Small Cell Lung Cancer : A Secondary Analysis of a Prospective Randomized Trial. Int J Radiat Oncol Biol Phys [Internet]. 2021;111(4):907–16. Available from: https://doi.org/10.1016/j.ijrobp.2021.07.035

Li C, Ngorsuraches S, Chou C, Chen L, Qian J. Critical Reviews in Oncology / Hematology Risk Factors of Fluoropyrimidine Induced Cardiotoxicity among Cancer Patients : A Systematic Review and Meta-analysis. Crit Rev Oncol / Hematol [Internet]. 2021;162(August 2020):103346. Available from: https://doi.org/10.1016/j.critrevonc.2021.103346

Omland T, Heck LS, Gulati G. The Role of Cardioprotection in Cancer Therapy Cardiotoxicity. JACC Cardiooncology. 2022;4(1).

Taylor C, Correa C, Duane FK, Aznar MC, Anderson SJ, Bergh J, et al. Estimating the Risks of Breast Cancer Radiotherapy : Evidence From Modern Radiation Doses to the Lungs and Heart and From Previous Randomized Trials. 2017;35(15):7–9.

Chun SG, Hu C, Choy H, Komaki RU, Timmerman RD, Schild SE, et al. Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non – Small-Cell Lung Cancer : A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial. 2017;35(1).

Zhu Q, Kirova YM, Cao L, Arsene-henry A, Chen J. Cardiotoxicity associated with radiotherapy in breast cancer : A question- based review with current literatures. Cancer Treat Rev [Internet]. 2018;68(December 2017):9–15. Available from: https://doi.org/10.1016/j.ctrv.2018.03.008

Darby SC, Ewertz M, Paul McGale, Bennet AM, Blom-Goldman U, Brønnum D, et al. Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. 2013;987–98.

Wisman BA, Nasution SA, Panggabean MM. Kardiotoksisitas Akibat Terapi Radiasi (Cardiotoxicity Complication of Radiotherapy). J Penyakit Dalam Indones. 2017;4(4):214–23.

Putu N, Ganapati D, Djakaria HM. Efek Samping Radiasi Pada Jantung. 2016;26–36.

Madan R, Benson R, Sharma DN, Julka PK, Rath GK. Radiation induced heart disease: Pathogenesis, management and review literature. J Egypt Natl Canc Inst [Internet]. 2015;27(4):187–93. Available from: http://dx.doi.org/10.1016/j.jnci.2015.07.005

Shah S, Gnanasegaran G, Sundberg-Cohon J, Buscombe JR. The heart: Anatomy, physiology and exercise physiology. Integr Cardiol Nucl Med Physicians A Guid to Nucl Med Physicians. 2009;3–22.

Sardaro A, Petruzzelli MF, D’Errico MP, Grimaldi L, Pili G, Portaluri M. Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints. Radiother Oncol [Internet]. 2012;103(2):133–42. Available from: http://dx.doi.org/10.1016/j.radonc.2012.02.008

Martinou M, Gaya A. Cardiac Complications After Radical Radiotherapy. Semin Oncol Nurs. 2013;40(2):178–85.

Gagliardi G, Constine SL, Moiseenko V, Correa C, Pierce JL, Allen MA, et al. Radiation Dose–Volume Effects in the Heart. Int J Radiat Oncol Biol Phys. 2010;76(3):S77–85.


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DOI: https://doi.org/10.26714/mki.5.3.2022.231-238

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